ldlrad3 low density lipoprotein receptor class A domain containing 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ldlrad3provided by ZNC
Official Full Name: low density lipoprotein receptor class A domain containing 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1533
See related: Ensembl:ENSDARG00000078600 AllianceGenome:ZFIN:ZDB-GENE-030131-1533
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb73h09; wu:fb73h09; zgc:194786
Summary: Predicted to be involved in receptor-mediated endocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human LDLRAD3 (low density lipoprotein receptor class A domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (37325054..37331356, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (36754495..36760797, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D1S3694 (e-PCR)
- UniSTS:474272

fc29g01.y1 (e-PCR)
- UniSTS:193463

fc89g05.x1 (e-PCR)
- UniSTS:194767

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: low-density lipoprotein receptor class A domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130607.1 → NP_001124079.1 low-density lipoprotein receptor class A domain-containing protein 3 precursor

See identical proteins and their annotated locations for NP_001124079.1

Status: PROVISIONAL

Source sequence(s)

BC163380

UniProtKB/TrEMBL

B3DJ30, B3DJ71

Related

ENSDARP00000097850.1, ENSDART00000111862.3

Conserved Domains (1) summary

cd00112
Location:111 → 145

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...