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    sh3glb1b SH3-domain GRB2-like endophilin B1b [ Danio rerio (zebrafish) ]

    Gene ID: 334911, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sh3glb1bprovided by ZNC
    Official Full Name
    SH3-domain GRB2-like endophilin B1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6851
    See related
    Ensembl:ENSDARG00000010956 AllianceGenome:ZFIN:ZDB-GENE-030131-6851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sh3glb1; im:5777505; wu:fa08f03; wu:fb13e12
    Summary
    Predicted to be involved in membrane organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in Golgi membrane and mitochondrial outer membrane. Predicted to be active in membrane. Orthologous to human SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sh3glb1b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (16174046..16194196)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (16505452..16525606)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene vav 3 guanine nucleotide exchange factor b Neighboring gene selenoprotein J Neighboring gene Rho guanine nucleotide exchange factor (GEF) 4 Neighboring gene APC membrane recruitment protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Tallafuss A, et al. Gene Expr Patterns, 2006 Jun. PMID 16448862
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endophilin-B1b
    Names
    SH3-domain GRB2-like endophilin B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256616.1 → NP_001243545.1  endophilin-B1b

      Status: VALIDATED

      Source sequence(s)
      CR788310
      UniProtKB/TrEMBL
      A0A2R8RNA7, A0A8M1NZI7, A0A8M3B7G3, B0V151
      Related
      ENSDARP00000045932.6, ENSDART00000045933.7
      Conserved Domains (2) summary
      cd11945
      Location:300 → 360
      SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1
      cl12013
      Location:21 → 249
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      16174046..16194196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163307.5 → XP_005163364.1  endophilin-B1b isoform X1

      UniProtKB/TrEMBL
      A0A0R4IS36, A0A8M2BAQ1, A0A8M3APC9
      Related
      ENSDARP00000138573.2, ENSDART00000157601.2
      Conserved Domains (2) summary
      cd11945
      Location:337 → 397
      SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1
      cl12013
      Location:21 → 286
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_068223128.1 → XP_068079229.1  endophilin-B1b isoform X2

      UniProtKB/TrEMBL
      A0A8M3APC9
      Related
      ENSDARP00000143647.1, ENSDART00000177639.2
    Nucleotide Protein Strain
    Heading Accession and Version

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