stim1a stromal interaction molecule 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stim1aprovided by ZNC
Official Full Name: stromal interaction molecule 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-914
See related: Ensembl:ENSDARG00000060723 AllianceGenome:ZFIN:ZDB-GENE-060503-914
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-24p1.5
Summary: Predicted to enable calcium channel regulator activity and calcium ion binding activity. Acts upstream of with a positive effect on axon extension involved in axon guidance. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (38221196..38297736)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (38319556..38394767)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stim1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
Title: SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of store-operated calcium channel activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stromal interaction molecule 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044799.1 → NP_001038264.1 stromal interaction molecule 1a precursor

Status: PROVISIONAL

Source sequence(s)

BX072550

UniProtKB/TrEMBL

A0A8M1N9C0, Q1LY88

Related

ENSDARP00000109796.2, ENSDART00000122134.4

Conserved Domains (3) summary

cd09573
Location:122 → 195

SAM_STIM1; SAM domain of STIM1 subfamily proteins

pfam16533
Location:338 → 435

SOAR; STIM1 Orai1-activating region

cl23720
Location:227 → 330

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

38221196..38297736

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173392.5 → XP_005173449.1 stromal interaction molecule 1a isoform X1

UniProtKB/TrEMBL

A0A8M2BKP3

Conserved Domains (3) summary

cd09573
Location:122 → 195

SAM_STIM1; SAM domain of STIM1 subfamily proteins

pfam16533
Location:338 → 435

SOAR; STIM1 Orai1-activating region

cl23720
Location:227 → 330

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_009291871.4 → XP_009290146.1 stromal interaction molecule 1a isoform X3

UniProtKB/TrEMBL

A0A2R8RIM0, A0A8M3AHN3

Related

ENSDARP00000145787.1, ENSDART00000188149.1

Conserved Domains (3) summary

pfam16533
Location:338 → 435

SOAR; STIM1 Orai1-activating region

cl15755
Location:122 → 195

SAM_superfamily; SAM (Sterile alpha motif )

cl23720
Location:227 → 330

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_005173393.5 → XP_005173450.1 stromal interaction molecule 1a isoform X2

UniProtKB/TrEMBL

A0A8M2BKR0

Conserved Domains (3) summary

cd09573
Location:122 → 195

SAM_STIM1; SAM domain of STIM1 subfamily proteins

pfam16533
Location:338 → 435

SOAR; STIM1 Orai1-activating region

cl23720
Location:227 → 330

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)