proca protein C (inactivator of coagulation factors Va and VIIIa), a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: procaprovided by ZNC
Official Full Name: protein C (inactivator of coagulation factors Va and VIIIa), aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060824-5
See related: Ensembl:ENSDARG00000093079 AllianceGenome:ZFIN:ZDB-GENE-060824-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: proc; zgc:63987; si:ch1073-188c16.3
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within proteolysis. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region. Predicted to be active in extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; central retinal vein occlusion; placental abruption; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (5457332..5475921, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (5545450..5564039, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc44a03.x1 (e-PCR)
- UniSTS:193871

fd12e12.x1 (e-PCR)
- UniSTS:204132

fc23d08.x1 (e-PCR)
- UniSTS:193148

fc28d06.x1 (e-PCR)
- UniSTS:193407

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vitamin K-dependent protein C

Names: procl

NP_956650.1

EC 3.4.21.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200356.1 → NP_956650.1 vitamin K-dependent protein C precursor

See identical proteins and their annotated locations for NP_956650.1

Status: PROVISIONAL

Source sequence(s)

BC053182

UniProtKB/TrEMBL

Q7T3B6

Related

ENSDARP00000138595.2, ENSDART00000172143.2

Conserved Domains (5) summary

smart00020
Location:197 → 424

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:23 → 84

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:85 → 119

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:195 → 427

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:128 → 165

FXa_inhibition; Coagulation Factor Xa inhibitory site