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    szl sizzled [ Danio rerio (zebrafish) ]

    Gene ID: 353294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    szlprovided by ZNC
    Official Full Name
    sizzledprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030530-1
    See related
    Ensembl:ENSDARG00000099637 AllianceGenome:ZFIN:ZDB-GENE-030530-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    slz; sfrp
    Summary
    Predicted to enable Wnt-protein binding activity. Acts upstream of or within several processes, including determination of dorsal identity; negative regulation of BMP signaling pathway; and protein stabilization. Predicted to be active in extracellular space. Is expressed in ectoderm; mesoderm; periderm; and tail bud. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See szl in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (371412..375892, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (348505..352985, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene periphilin-1 Neighboring gene prickle homolog 1a Neighboring gene DNA-binding protein RFX7 Neighboring gene protogenin homolog b (Gallus gallus)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein. Martyn U, et al. Dev Biol, 2003 Aug 1. PMID 12885555
    2. Non-acylated Wnts Can Promote Signaling. Speer KF, et al. Cell Rep, 2019 Jan 22. PMID 30673610, Free PMC Article
    3. Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning. Pomreinke AP, et al. Elife, 2017 Aug 31. PMID 28857744, Free PMC Article
    4. An alternative evolutionary pathway for the twin-tail goldfish via szl gene mutation. Abe G, et al. J Exp Zool B Mol Dev Evol, 2018 Jun. PMID 29947476, Free PMC Article
    5. Regulation of bone morphogenetic proteins in early embryonic development. Yamamoto Y, et al. Naturwissenschaften, 2004 Nov. PMID 15517134

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of szl, a secreted frizzled-related protein.
      Title: The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within determination of dorsal identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of dorsal identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within developmental pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sizzled
    Names
    mercedes
    mes
    ogo
    ogon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181663.1 → NP_858049.1  sizzled precursor

      See identical proteins and their annotated locations for NP_858049.1

      Status: PROVISIONAL

      Source sequence(s)
      AB093587
      UniProtKB/TrEMBL
      Q1JPW5, Q7SX78
      Related
      ENSDARP00000133257.1, ENSDART00000165705.3
      Conserved Domains (2) summary
      cd03580
      Location:152 → 282
      NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...
      cl02447
      Location:19 → 158
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      371412..375892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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