ccnb1 cyclin B1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccnb1provided by ZNC
Official Full Name: cyclin B1provided by ZNC
Primary source: ZFIN:ZDB-GENE-000406-10
See related: Ensembl:ENSDARG00000051923 AllianceGenome:ZFIN:ZDB-GENE-000406-10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ccnb; cycb; spct; cb267; cycb1; spr(l); wu:fa19g04; wu:fb16d01; wu:fb16e07; wu:fi21c01
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within oocyte maturation. Predicted to be part of cyclin B1-CDK1 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including nervous system; oocyte; pectoral fin; trunk mesenchyme; and unfertilized egg. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (54711393..54714749, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (54088557..54091913, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of zygotic Cyclin B1 does not stop cells from dividing, rather it causes an abnormal and elongated progression through the G2 and M phases of the cell cycle. Study concludes that, although Cyclin B1 is critical for cells to enter mitosis, another cell cycle protein may be cooperating with Cdk1 at the G2/M checkpoint to sustain a partly functional Mitosis Promoting Factor.
Title: Lack of Cyclin B1 in zebrafish causes lengthening of G2 and M phases.
The findings suggest that cyclin B1 mRNA-Staufen1 protein complexes are transported toward the animal pole of zebrafish oocytes by the plus-end-directed motor protein Kinesin1 along microtubules, and that a common mRNA transport machinery functions in zebrafish and Xenopus oocytes, although its transport direction is opposite due to different organizations of microtubules.
Title: Staufen1, Kinesin1 and microtubule function in cyclin B1 mRNA transport to the animal polar cytoplasm of zebrafish oocytes.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1, p21, PCNA and cdk2, but only weakly influences cyclin B1, cyclin B2 and cyclin E1 expression.
Title: Circadian clock regulation of the cell cycle in the zebrafish intestine.
the sequence in the coding region of cyclin B1 mRNA plays an important role as a cis-acting element in both subcellular localization and translational timing of mRNA
Title: A cis-acting element in the coding region of cyclin B1 mRNA couples subcellular localization to translational timing.
Reporter mRNAs with the whole cyclin B1 sequence precisely mimic the localization & translation of endogenous cyclin B1 mRNA. mRNAs containing cyclin B1 3' UTR but lacking ORFs had abnormal localization & precocious translational activation.
Title: Transgenic zebrafish reveals novel mechanisms of translational control of cyclin B1 mRNA in oocytes.
zebrafish cyclin B1 3'UTR was quantitatively less effective at stimulating polyadenylation and translation compared to the Xenopus cyclin B1 3'UTR during both zebrafish and Xenopus oocyte maturation
Title: Analyses of zebrafish and Xenopus oocyte maturation reveal conserved and diverged features of translational regulation of maternal cyclin B1 mRNA.

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General gene information

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Markers

aa605815 (e-PCR)
- UniSTS:186899

Z22208 (e-PCR)
- UniSTS:204685

fb16d01.x1 (e-PCR)
- UniSTS:202966

fi21c01.x1 (e-PCR)
- UniSTS:204502

fb16e07.x1 (e-PCR)
- UniSTS:190191

fb16e07.x1 (e-PCR)
- UniSTS:190192

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oocyte maturation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin B1-CDK1 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G2/mitotic-specific cyclin-B1

Names: cyclinB; etID61116.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131513.1 → NP_571588.1 G2/mitotic-specific cyclin-B1

See identical proteins and their annotated locations for NP_571588.1

Status: PROVISIONAL

Source sequence(s)

AB040435

UniProtKB/TrEMBL

Q9IB44

Related

ENSDARP00000063356.4, ENSDART00000063357.6

Conserved Domains (2) summary

pfam00134
Location:140 → 262

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:267 → 385

Cyclin_C; Cyclin, C-terminal domain