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    ckmb creatine kinase, muscle b [ Danio rerio (zebrafish) ]

    Gene ID: 794752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ckmbprovided by ZNC
    Official Full Name
    creatine kinase, muscle bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2128
    See related
    Ensembl:ENSDARG00000040565 AllianceGenome:ZFIN:ZDB-GENE-040426-2128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ckm3; zgc:64204; zgc:92070; wu:fb55e09
    Summary
    Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in extracellular space. Is expressed in adaxial cell; head; heart; musculature system; and pectoral fin. Orthologous to human CKM (creatine kinase, M-type). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ckmb in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23643718..23646968, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (23708453..23711808, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:dkey-182i3.11 Neighboring gene MAP/microtubule affinity-regulating kinase 4b Neighboring gene kinesin light chain 3 Neighboring gene excision repair cross-complementation group 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myomesin is part of an integrity pathway that responds to sarcomere damage and disease. Prill K, et al. PLoS One, 2019. PMID 31644553, Free PMC Article
    2. Infertility control of transgenic fluorescent zebrafish with targeted mutagenesis of the dnd1 gene by CRISPR/Cas9 genome editing. Chu WK, et al. Front Genet, 2023. PMID 36713075, Free PMC Article
    3. Comprehensive transcriptome analysis reveal key molecular events in the pearl oyster after pre-grafting conditioning. Jiao Y, et al. Fish Shellfish Immunol, 2019 Sep. PMID 31195116
    4. Protein expression patterns in zebrafish skeletal muscle: initial characterization and the effects of hypoxic exposure. Bosworth CA 4th, et al. Proteomics, 2005 Apr. PMID 15732137
    5. Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts. Marques IJ, et al. J Comp Physiol B, 2008 Jan. PMID 17828398, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64204, MGC92070

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables creatine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables creatine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphocreatine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphocreatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    creatine kinase, muscle b
    NP_001099153.1
    XP_005157650.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105683.1 → NP_001099153.1  creatine kinase, muscle b

      See identical proteins and their annotated locations for NP_001099153.1

      Status: PROVISIONAL

      Source sequence(s)
      BC153631
      UniProtKB/TrEMBL
      A8E5L0
      Related
      ENSDARP00000130760.2, ENSDART00000168845.2
      Conserved Domains (1) summary
      cd00716
      Location:16 → 372
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      23643718..23646968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157593.2 → XP_005157650.1  creatine kinase, muscle b isoform X1

      See identical proteins and their annotated locations for XP_005157650.1

      UniProtKB/TrEMBL
      A0A0R4IA56, A0A8N7XJ25, F6P1F4, Q7T306
      Related
      ENSDARP00000059365.5, ENSDART00000059366.7
      Conserved Domains (1) summary
      cd00716
      Location:16 → 372
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
    Nucleotide Protein Strain
    Heading Accession and Version

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