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    ppdpfa pancreatic progenitor cell differentiation and proliferation factor a [ Danio rerio (zebrafish) ]

    Gene ID: 338304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppdpfaprovided by ZNC
    Official Full Name
    pancreatic progenitor cell differentiation and proliferation factor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030219-204
    See related
    Ensembl:ENSDARG00000007682 AllianceGenome:ZFIN:ZDB-GENE-030219-204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb1048; fb65a03; c20orf149; zgc:66181; c20orf149a; id:ibd5154; wu:fb65a03
    Summary
    Acts upstream of or within cell fate specification; cell population proliferation; and exocrine pancreas development. Is expressed in several structures, including exocrine cell; mesoderm; musculature system; pancreatic system; and sensory system. Orthologous to human PPDPF (pancreatic progenitor cell differentiation and proliferation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppdpfa in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23213329..23216035)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23192090..23194796)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch211-196c10.15 Neighboring gene tpd52 like 2a Neighboring gene PTK6 protein tyrosine kinase 6a Neighboring gene uncharacterized LOC137496344 Neighboring gene nucleolar protein 4-like a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. Geusz RJ, et al. Elife, 2021 Feb 5. PMID 33544077, Free PMC Article
    2. Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish. Zhang S, et al. Dis Model Mech, 2014 Jul. PMID 24652768, Free PMC Article
    3. Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish. Jiang Z, et al. PLoS Biol, 2008 Nov 25. PMID 19067490, Free PMC Article
    4. A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish. Singh SP, et al. Development, 2022 Jan 15. PMID 35088828
    5. scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain. Brown C, et al. Cell Physiol Biochem, 2021 May 5. PMID 33945241

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development.
      Title: Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pancreatic progenitor cell differentiation and proliferation factor A
    Names
    exdpf
    exocrine differentiation and proliferation factor A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200079.1 → NP_956373.1  pancreatic progenitor cell differentiation and proliferation factor A

      See identical proteins and their annotated locations for NP_956373.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057474
      UniProtKB/Swiss-Prot
      Q6PFP3
      Related
      ENSDARP00000031112.4, ENSDART00000032996.6
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 108
      PPDFL; Differentiation and proliferation regulator

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      23213329..23216035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFP3.1 GenPept UniProtKB/Swiss-Prot:Q6PFP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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