chac1 ChaC, cation transport regulator homolog 1 (E. coli) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chac1provided by ZNC
Official Full Name: ChaC, cation transport regulator homolog 1 (E. coli)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1957
See related: Ensembl:ENSDARG00000070426 AllianceGenome:ZFIN:ZDB-GENE-030131-1957
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb1014; wu:fb93a10; wu:fp64e03
Summary: Predicted to enable Notch binding activity and glutathione specific gamma-glutamylcyclotransferase activity. Acts upstream of or within with a positive effect on glutathione catabolic process. Predicted to be located in trans-Golgi network. Predicted to be active in cytoplasm. Is expressed in several structures, including alar plate midbrain region; nervous system; optic vesicle; periderm; and solid lens vesicle. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (28266935..28269464)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (28367845..28370374)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The study thus identifies Chac1 and the consequent change in intracellular glutathione redox potential as important upstream activators of calcium signaling during development.
Title: The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Notch binding	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione specific gamma-glutamylcyclotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione specific gamma-glutamylcyclotransferase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect glutathione catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glutathione catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect glutathione catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutathione-specific gamma-glutamylcyclotransferase 1

Names: ChaC, cation transport regulator-like 1; cation transport regulator-like protein 1; gamma-GCG 1

NP_001103596.2

EC 4.3.2.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110126.2 → NP_001103596.2 glutathione-specific gamma-glutamylcyclotransferase 1

See identical proteins and their annotated locations for NP_001103596.2

Status: VALIDATED

Source sequence(s)

BC153392, CK400274

UniProtKB/Swiss-Prot

Q5SPB6

UniProtKB/TrEMBL

A4QNY6

Related

ENSDARP00000094107.4, ENSDART00000103330.5

Conserved Domains (2) summary

COG3703
Location:5 → 190

ChaC; Cation transport regulator ChaC [Inorganic ion transport and metabolism]

pfam04752
Location:13 → 183

ChaC; ChaC-like protein