stk3 serine/threonine kinase 3 (STE20 homolog, yeast) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stk3provided by ZNC
Official Full Name: serine/threonine kinase 3 (STE20 homolog, yeast)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2845
See related: Ensembl:ENSDARG00000011312 AllianceGenome:ZFIN:ZDB-GENE-030131-2845
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55383; wu:fc19e11
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within camera-type eye development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human STK3 (serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (32807236..32820107)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (33220116..33232987)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network.
Title: Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network.
Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish.
Title: Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein tetramerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase 3

Names: mst2

NP_955966.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199672.1 → NP_955966.1 serine/threonine-protein kinase 3

See identical proteins and their annotated locations for NP_955966.1

Status: PROVISIONAL

Source sequence(s)

BC048033

UniProtKB/Swiss-Prot

Q7ZUQ3

UniProtKB/TrEMBL

B2GP54

Related

ENSDARP00000015367.5, ENSDART00000008698.6

Conserved Domains (3) summary

cd06612
Location:22 → 277

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:26 → 277

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam11629
Location:438 → 485

Mst1_SARAH; C terminal SARAH domain of Mst1