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    cct3 chaperonin containing TCP1, subunit 3 (gamma) [ Danio rerio (zebrafish) ]

    Gene ID: 192327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cct3provided by ZNC
    Official Full Name
    chaperonin containing TCP1, subunit 3 (gamma)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-5
    See related
    Ensembl:ENSDARG00000016173 AllianceGenome:ZFIN:ZDB-GENE-020419-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    chunp6930; wu:fb13f04; wu:fb52a02; wu:fj48b06
    Summary
    Predicted to enable unfolded protein binding activity. Acts upstream of or within embryonic eye morphogenesis and negative regulation of retinal cell programmed cell death. Predicted to be part of chaperonin-containing T-complex. Orthologous to human CCT3 (chaperonin containing TCP1 subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cct3 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (30408787..30421207, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (30450860..30463280, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene cortexin-2 Neighboring gene transmembrane protein 79b Neighboring gene protein disulfide isomerase family A, member 7 Neighboring gene platelet endothelial aggregation receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth. Berger J, et al. PLoS Genet, 2022 Jun. PMID 35737712, Free PMC Article
    2. In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly. Berger J, et al. Cell Rep, 2018 Jan 9. PMID 29320728
    3. A cellular retinoic acid-binding protein from zebrafish (Danio rerio): cDNA sequence, phylogenetic analysis, mRNA expression, and gene linkage mapping. Sharma MK, et al. Gene, 2003 Jun 5. PMID 12853146
    4. Identification of chaperonin CCT gamma subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant. Matsuda N, et al. Development, 2004 May. PMID 15056614
    5. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Zhang C, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31546038

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that the gamma subunit of chaperonin CCT plays an essential role in retinotectal development.
      Title: Identification of chaperonin CCT gamma subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    T-complex protein 1 subunit gamma
    Names
    no tectal neuron
    ntn
    subunit 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173250.1 → NP_775357.1  T-complex protein 1 subunit gamma

      See identical proteins and their annotated locations for NP_775357.1

      Status: PROVISIONAL

      Source sequence(s)
      AF506209
      UniProtKB/TrEMBL
      Q8JHI7
      Related
      ENSDARP00000004738.7, ENSDART00000003752.9
      Conserved Domains (2) summary
      cd03337
      Location:5 → 524
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02344
      Location:5 → 528
      chap_CCT_gamma; T-complex protein 1, gamma subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      30408787..30421207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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