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    cdk5rap2 CDK5 regulatory subunit associated protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 334460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdk5rap2provided by ZNC
    Official Full Name
    CDK5 regulatory subunit associated protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6392
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-6392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cep215; fi74c05; zgc:55582; wu:fi74c05
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in centrosome cycle and regulation of Golgi organization. Predicted to be located in cytoplasm and microtubule organizing center. Predicted to be active in Golgi apparatus and centrosome. Human ortholog(s) of this gene implicated in Seckel syndrome; microcephaly; and primary autosomal recessive microcephaly 3. Orthologous to human CDK5RAP2 (CDK5 regulatory subunit associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cdk5rap2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (4607941..4695559, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (4443377..4531003, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 188 Neighboring gene dolichol kinase Neighboring gene si:dkey-102g19.3 Neighboring gene calmodulin regulated spectrin-associated protein 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. Sepulveda G, et al. Elife, 2018 Apr 30. PMID 29708497, Free PMC Article
    2. Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. Wang Z, et al. J Biol Chem, 2010 Jul 16. PMID 20466722, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDK5 regulatory subunit-associated protein 2
    Names
    myomegalin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430821.1 → NP_001417750.1  CDK5 regulatory subunit-associated protein 2

      Status: VALIDATED

      Source sequence(s)
      BX469935, CR388125

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      4607941..4695559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009295111.4 → XP_009293386.1  CDK5 regulatory subunit-associated protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M3ALW0
      Conserved Domains (6) summary
      COG1196
      Location:288 → 1035
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:833 → 1573
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07989
      Location:55 → 123
      Cnn_1N; Centrosomin N-terminal motif 1
      cl00459
      Location:834 → 929
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:266 → 343
      DUF342; Protein of unknown function (DUF342)
      cl19758
      Location:317 → 381
      FH2; Formin Homology 2 Domain

    2. XM_068215794.1 → XP_068071895.1  CDK5 regulatory subunit-associated protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AL75

    3. XM_021468756.2 → XP_021324431.1  CDK5 regulatory subunit-associated protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AL75
      Conserved Domains (2) summary
      pfam07989
      Location:23 → 91
      Cnn_1N; Centrosomin N-terminal motif 1
      cl25732
      Location:256 → 911
      SMC_N; RecF/RecN/SMC N terminal domain

    4. XM_009295110.4 → XP_009293385.1  CDK5 regulatory subunit-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M3B4F9
      Conserved Domains (5) summary
      COG1196
      Location:325 → 1126
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1930 → 2618
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07776
      Location:5 → 63
      zf-AD; Zinc-finger associated domain (zf-AD)
      cl00459
      Location:874 → 969
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19758
      Location:357 → 434
      FH2; Formin Homology 2 Domain

    5. XM_068215792.1 → XP_068071893.1  CDK5 regulatory subunit-associated protein 2 isoform X6

    6. XM_009295109.4 → XP_009293384.1  CDK5 regulatory subunit-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AL71
      Conserved Domains (5) summary
      COG1196
      Location:325 → 1126
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:800 → 1613
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07776
      Location:5 → 63
      zf-AD; Zinc-finger associated domain (zf-AD)
      cl00459
      Location:874 → 969
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19758
      Location:357 → 434
      FH2; Formin Homology 2 Domain

    7. XM_009295113.4 → XP_009293388.1  CDK5 regulatory subunit-associated protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AWK4
      Conserved Domains (5) summary
      COG1196
      Location:325 → 1126
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:800 → 1613
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07776
      Location:5 → 63
      zf-AD; Zinc-finger associated domain (zf-AD)
      cl00459
      Location:874 → 969
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19758
      Location:357 → 434
      FH2; Formin Homology 2 Domain

    8. XM_009295108.4 → XP_009293383.1  CDK5 regulatory subunit-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ATJ9
      Conserved Domains (5) summary
      COG1196
      Location:325 → 1126
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:800 → 1613
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07776
      Location:5 → 63
      zf-AD; Zinc-finger associated domain (zf-AD)
      cl00459
      Location:874 → 969
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19758
      Location:357 → 434
      FH2; Formin Homology 2 Domain

    9. XM_068215795.1 → XP_068071896.1  CDK5 regulatory subunit-associated protein 2 isoform X10

    10. XM_068215798.1 → XP_068071899.1  CDK5 regulatory subunit-associated protein 2 isoform X13

    11. XM_068215797.1 → XP_068071898.1  CDK5 regulatory subunit-associated protein 2 isoform X12

    12. XM_068215793.1 → XP_068071894.1  CDK5 regulatory subunit-associated protein 2 isoform X8

    13. XM_068215796.1 → XP_068071897.1  CDK5 regulatory subunit-associated protein 2 isoform X11

    14. XM_009295114.4 → XP_009293389.1  CDK5 regulatory subunit-associated protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8M3ATK8
      Conserved Domains (5) summary
      COG1196
      Location:325 → 1126
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:800 → 1613
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07776
      Location:5 → 63
      zf-AD; Zinc-finger associated domain (zf-AD)
      cl00459
      Location:874 → 969
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19758
      Location:357 → 434
      FH2; Formin Homology 2 Domain

    15. XM_068215799.1 → XP_068071900.1  CDK5 regulatory subunit-associated protein 2 isoform X14

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199901.2: Suppressed sequence

      Description
      NM_199901.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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