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    notum1b notum, palmitoleoyl-protein carboxylesterase b [ Danio rerio (zebrafish) ]

    Gene ID: 436917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    notum1bprovided by ZNC
    Official Full Name
    notum, palmitoleoyl-protein carboxylesterase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-391
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040718-391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92474
    Summary
    Predicted to enable palmitoleyl hydrolase activity. Predicted to be involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See notum1b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (45244612..45252032, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (44830218..44833697, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496743 Neighboring gene Fc receptor-like protein 5 Neighboring gene uncharacterized LOC137496744 Neighboring gene transmembrane channel-like 8 Neighboring gene transmembrane channel-like 6b Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene pyrroline-5-carboxylate reductase 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Lu F, et al. Sci Rep, 2023 Feb 23. PMID 36823429, Free PMC Article
    2. A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway. Flowers GP, et al. Development, 2012 Jul. PMID 22669824, Free PMC Article
    3. Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Song Y, et al. Front Cell Dev Biol, 2021. PMID 35111746, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoleyl hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein depalmitoleylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    inactive palmitoleoyl-protein carboxylesterase notum1b
    Names
    notum pectinacetylesterase 1b
    notum pectinacetylesterase homolog 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423935.1 → NP_001410864.1  inactive palmitoleoyl-protein carboxylesterase notum1b precursor

      Status: VALIDATED

      Source sequence(s)
      MW118490

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      45244612..45252032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002644.1: Suppressed sequence

      Description
      NM_001002644.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DFZ6.1 GenPept UniProtKB/Swiss-Prot:Q6DFZ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials