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    micall2a mical-like 2a [ Danio rerio (zebrafish) ]

    Gene ID: 327198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    micall2aprovided by ZNC
    Official Full Name
    mical-like 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5409
    See related
    Ensembl:ENSDARG00000102366 AllianceGenome:ZFIN:ZDB-GENE-030131-5409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd16d06; micall2; zgc:55358; wu:fd16d06; wu:fd16d07
    Summary
    Predicted to enable metal ion binding activity. Is expressed in several structures, including cardiovascular system; lateral line; neural tube; ventral mesoderm; and yolk syncytial layer. Orthologous to human MICALL2 (MICAL like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See micall2a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (43102000..43135493)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (42395995..42429478)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 1 Neighboring gene si:dkey-43p13.5 Neighboring gene chromo domain-containing protein cec-1-like Neighboring gene uncharacterized LOC137490738

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and expression analysis of mical family genes in zebrafish. Xue Y, et al. J Genet Genomics, 2010 Oct. PMID 21035094
    2. Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Nittoli V, et al. Gene X, 2019 Jun. PMID 31193955, Free PMC Article
    3. Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Chestnut B, et al. Dev Dyn, 2020 Feb. PMID 31705559, Free PMC Article
    4. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that micall2a is detected in blood vessels.
      Title: Identification and expression analysis of mical family genes in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MICAL-like protein 2a
    Names
    mical-like 2
    molecule interacting with CasL-like 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327787.1 → NP_001314716.1  MICAL-like protein 2a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      BX908797
      UniProtKB/TrEMBL
      A0A0R4INF7, A0A8M1P8A2, A0A8M2BBC6, A0A8M2BBR4
      Related
      ENSDARP00000135432.1, ENSDART00000162096.2
      Conserved Domains (3) summary
      cd09444
      Location:237 → 291
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      pfam00307
      Location:5 → 102
      CH; Calponin homology (CH) domain
      pfam12130
      Location:624 → 750
      DUF3585; Protein of unknown function (DUF3585)

    RNA

    1. NR_137174.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BX908797
      Related
      ENSDART00000165708.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      43102000..43135493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215918.1 → XP_068072019.1  MICAL-like protein 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBH3

    2. XM_068215921.1 → XP_068072022.1  MICAL-like protein 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BBC6, A0A8M2BBR4
    Nucleotide Protein Strain
    Heading Accession and Version

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