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    klf6a Kruppel like factor 6a [ Danio rerio (zebrafish) ]

    Gene ID: 280650, updated on 9-Dec-2024

    Summary

    Official Symbol
    klf6aprovided by ZNC
    Official Full Name
    Kruppel like factor 6aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021115-9
    See related
    Ensembl:ENSDARG00000029072 AllianceGenome:ZFIN:ZDB-GENE-021115-9
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    klf6; cb538; copeb; wu:fb76d04; wu:fb92h03; wu:fe26g06; wu:fk78f12
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including erythrocyte maturation; optic nerve formation; and regulation of hematopoietic stem cell migration. Is active in chromatin. Is expressed in several structures, including cardiovascular system; digestive system; intermediate cell mass of mesoderm; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in prostate cancer and stomach cancer. Orthologous to human KLF6 (KLF transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See klf6a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (4141479..4148914, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (4109692..4117127, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489279 Neighboring gene phosphofructokinase, platelet a Neighboring gene cyclin Y Neighboring gene gap junction protein delta 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization PubMed 
    acts_upstream_of_or_within digestive tract development PubMed 
    acts_upstream_of_or_within endothelial cell migration PubMed 
    acts_upstream_of_or_within erythrocyte maturation PubMed 
    acts_upstream_of_or_within liver development PubMed 
    acts_upstream_of_or_within optic nerve formation PubMed 
    acts_upstream_of_or_within organ growth PubMed 
    acts_upstream_of_or_within pancreas development PubMed 
    acts_upstream_of_or_within regulation of hematopoietic stem cell migration PubMed 
    acts_upstream_of_or_within regulation of hematopoietic stem cell migration PubMed 
    acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation PubMed 
    acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    is_active_in chromatin  
    located_in chromatin PubMed 

    General protein information

    Preferred Names
    Krueppel-like factor 6a
    Names
    core promoter element binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201461.2 → NP_958869.2  Krueppel-like factor 6a

      Status: VALIDATED

      Source sequence(s)
      CT704401, CT734412, CU462914
      UniProtKB/TrEMBL
      A0A8N7V055, F1R7F0
      Related
      ENSDARP00000037789.5, ENSDART00000033494.6
      Conserved Domains (3) summary
      COG5048
      Location:171 → 265
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:246 → 271
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      4141479..4148914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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