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    orc4 origin recognition complex, subunit 4 [ Danio rerio (zebrafish) ]

    Gene ID: 406462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    orc4provided by ZNC
    Official Full Name
    origin recognition complex, subunit 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2224
    See related
    Ensembl:ENSDARG00000101161 AllianceGenome:ZFIN:ZDB-GENE-040426-2224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc50c03; zgc:85772; wu:fc50c03
    Summary
    Predicted to enable DNA replication origin binding activity. Acts upstream of or within cilium assembly. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See orc4 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (1748463..1762144, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (894094..907794, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495831 Neighboring gene activin A receptor type 2Ab Neighboring gene zgc:158417 Neighboring gene zgc:113442

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors. Maerz LD, et al. Eur J Hum Genet, 2019 May. PMID 30696958, Free PMC Article
    2. Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors. Idilli AI, et al. Cancers (Basel), 2020 Apr 22. PMID 32331249, Free PMC Article
    3. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article
    4. Telomerase Is Essential for Zebrafish Heart Regeneration. Bednarek D, et al. Cell Rep, 2015 Sep 8. PMID 26321646, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of origin recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213183.1 → NP_998348.1  origin recognition complex subunit 4

      See identical proteins and their annotated locations for NP_998348.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067614
      UniProtKB/TrEMBL
      Q6NWF3
      Related
      ENSDARP00000130427.1, ENSDART00000171313.2
      Conserved Domains (3) summary
      smart00382
      Location:59 → 215
      AAA; ATPases associated with a variety of cellular activities
      pfam13191
      Location:34 → 188
      AAA_16; AAA ATPase domain
      pfam14629
      Location:226 → 403
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      1748463..1762144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168697.3 → XP_005168754.1  origin recognition complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFZ9, F1QRE0
      Related
      ENSDARP00000141716.1, ENSDART00000167928.2
      Conserved Domains (3) summary
      smart00382
      Location:59 → 215
      AAA; ATPases associated with a variety of cellular activities
      pfam13191
      Location:34 → 188
      AAA_16; AAA ATPase domain
      pfam14629
      Location:226 → 403
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
    Nucleotide Protein
    Heading Accession and Version

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