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    tnn tenascin N [ Danio rerio (zebrafish) ]

    Gene ID: 30234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tnnprovided by ZNC
    Official Full Name
    tenascin Nprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-262
    See related
    Ensembl:ENSDARG00000024829 AllianceGenome:ZFIN:ZDB-GENE-990415-262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tnw; tenw; zgc:110729
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell-matrix adhesion and neuron projection extension. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in corneal epithelium and head. Orthologous to human TNN (tenascin N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tnn in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (35509418..35567016, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (35526961..35584564, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene tenascin R (restrictin, janusin) Neighboring gene KIAA0040 ortholog Neighboring gene mitochondrial ribosomal protein S14 Neighboring gene calcyclin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tenascin-W: Discovery, Evolution, and Future Prospects. Degen M, et al. Front Immunol, 2020. PMID 33603752, Free PMC Article
    2. Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development. Scherberich A, et al. J Cell Sci, 2004 Feb 1. PMID 14709716
    3. Low temperature mitigates cardia bifida in zebrafish embryos. Lin CY, et al. PLoS One, 2013. PMID 23922799, Free PMC Article
    4. Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. Lou SS, et al. J Cell Biol, 2015 Apr 27. PMID 25918227, Free PMC Article
    5. Cellular and molecular bases of axonal pathfinding during embryogenesis of the fish central nervous system. Bernhardt RR. J Neurobiol, 1999 Jan. PMID 10027569

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tenascin-W: Discovery, Evolution, and Future Prospects.
      Title: Tenascin-W: Discovery, Evolution, and Future Prospects.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tenascin-N
    Names
    etID309873.2
    tenascin W

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131036.2 → NP_571111.2  tenascin-N precursor

      See identical proteins and their annotated locations for NP_571111.2

      Status: VALIDATED

      Source sequence(s)
      FP236741
      UniProtKB/TrEMBL
      A0A8M1P6P9, A0A8M3B7S9, B0S6K5
      Related
      ENSDARP00000071646.5, ENSDART00000077178.7
      Conserved Domains (4) summary
      cd00087
      Location:704 → 915
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam00041
      Location:523 → 602
      fn3; Fibronectin type III domain
      pfam04863
      Location:133 → 163
      EGF_alliinase; Alliinase EGF-like domain
      pfam07974
      Location:224 → 251
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      35509418..35567016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171265.4 → XP_005171322.1  tenascin-N isoform X2

      See identical proteins and their annotated locations for XP_005171322.1

      UniProtKB/TrEMBL
      A0A8M2BIP3, A0A8M3B7S9, B0S6K6
      Related
      ENSDARP00000033045.7, ENSDART00000029006.9
      Conserved Domains (5) summary
      cd00063
      Location:435 → 517
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00087
      Location:616 → 827
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam00041
      Location:257 → 333
      fn3; Fibronectin type III domain
      pfam04863
      Location:133 → 163
      EGF_alliinase; Alliinase EGF-like domain
      pfam07974
      Location:224 → 251
      EGF_2; EGF-like domain

    2. XM_005171264.5 → XP_005171321.1  tenascin-N isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIJ7, A0A8M3B7S9, F1QSR3
      Related
      ENSDARP00000110076.2, ENSDART00000125298.3
      Conserved Domains (4) summary
      cd00087
      Location:792 → 1003
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam00041
      Location:523 → 602
      fn3; Fibronectin type III domain
      pfam04863
      Location:133 → 163
      EGF_alliinase; Alliinase EGF-like domain
      pfam07974
      Location:224 → 251
      EGF_2; EGF-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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