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    neil1 nei-like DNA glycosylase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    neil1provided by ZNC
    Official Full Name
    nei-like DNA glycosylase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-994
    See related
    Ensembl:ENSDARG00000018061 AllianceGenome:ZFIN:ZDB-GENE-040426-994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56361
    Summary
    Predicted to enable DNA N-glycosylase activity and DNA-(apurinic or apyrimidinic site) endonuclease activity. Predicted to be involved in base-excision repair. Predicted to be active in nucleus. Orthologous to human NEIL1 (nei like DNA glycosylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See neil1 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (26827140..26833102, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (26383938..26389900, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase XII Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene COMM domain containing 4 Neighboring gene semaphorin 7A (JohnMiltonHagen blood group)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness. Zhao H, et al. Curr Biol, 2018 Oct 22. PMID 30318355
    2. Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Zaksauskaite R, et al. Sci Adv, 2021 Jan. PMID 33514542, Free PMC Article
    3. Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. Gavriouchkina D, et al. PLoS One, 2010 Sep 7. PMID 20830285, Free PMC Article
    4. Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. Shin U, et al. DNA Repair (Amst), 2021 Nov. PMID 34390914
    5. Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Arcanjo C, et al. Aquat Toxicol, 2018 Jul. PMID 29751158

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56361

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease 8-like 1
    Names
    nei endonuclease VIII-like 1
    NP_956577.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200283.2 → NP_956577.2  endonuclease 8-like 1

      Status: VALIDATED

      Source sequence(s)
      EH450678, EH473716, EH538356, EH577930
      UniProtKB/TrEMBL
      A0A8M1PB19, Q6TGW9
      Related
      ENSDARP00000017787.8, ENSDART00000014052.9
      Conserved Domains (4) summary
      cd08967
      Location:1 → 135
      MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
      pfam06831
      Location:167 → 205
      H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
      pfam09292
      Location:269 → 307
      Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
      cl17171
      Location:331 → 393
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      26827140..26833102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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