hey1 hes-related family bHLH transcription factor with YRPW motif 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hey1provided by ZNC
Official Full Name: hes-related family bHLH transcription factor with YRPW motif 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-000607-70
See related: Ensembl:ENSDARG00000070538 AllianceGenome:ZFIN:ZDB-GENE-000607-70
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: id:ibd1292; zgc:110572
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate specification. Predicted to be active in nucleus. Is expressed in several structures, including germ ring; mesoderm; musculature system; nervous system; and pharyngeal arch. Orthologous to human HEY1 (hes related family bHLH transcription factor with YRPW motif 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (31797567..31802275, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (32210254..32214962, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1.
Title: Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1.
Notch signaling via Hey1 and Id2b regulates Muller glia's regenerative response to retinal injury.
Title: Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury.
abrogation of Hey1 function in adult pallial Neural stem cells in vivo, including quiescent Neural stem cells, leads to their differentiation without affecting their proliferation state.
Title: Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signalling cascade in the vertebrate adult brain.
Expression of seven hairy/E(spl) (her) genes is reported in three neurogenic areas of the adult zebrafish brain (telencephalon, hypothalamus, and midbrain) in relation to radial glia, proliferation, and neurogenesis.
Title: Expression of hairy/enhancer of split genes in neural progenitors and neurogenesis domains of the adult zebrafish brain.
hey1 represents a target of Delta-Notch signaling dynamically expressed during somite formation in zebrafish
Title: Characterization of hey bHLH genes in teleost fish.

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General gene information

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Markers

fc03c05.y1 (e-PCR)
- UniSTS:192107

fc25e07.x1 (e-PCR)
- UniSTS:193258

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circulatory system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hairy/enhancer-of-split related with YRPW motif protein 1

Names: Herp1; basic helix-loop-helix transcription factor; hairy/enhancer-of-split related with YRPW motif 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212561.1 → NP_997726.1 hairy/enhancer-of-split related with YRPW motif protein 1

See identical proteins and their annotated locations for NP_997726.1

Status: PROVISIONAL

Source sequence(s)

AJ510221

UniProtKB/Swiss-Prot

Q8AXV6

UniProtKB/TrEMBL

B2GNV6

Related

ENSDARP00000094416.4, ENSDART00000103640.5

Conserved Domains (2) summary

smart00511
Location:119 → 165

ORANGE; Orange domain

cd00083
Location:49 → 106

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...