nav3 neuron navigator 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nav3provided by ZNC
Official Full Name: neuron navigator 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-021205-1
See related: Ensembl:ENSDARG00000005476 AllianceGenome:ZFIN:ZDB-GENE-021205-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb419; wu:fa05f06
Summary: Enables actin binding activity. Acts upstream of or within liver morphogenesis and pancreas development. Located in Golgi apparatus; filopodium; and lamellipodium. Is expressed in several structures, including cardiovascular system; digestive system; liver primordium; nervous system; and periderm. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human NAV3 (neuron navigator 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 50

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (20622794..20990445)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (21091822..21269470)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuron navigator 3 (NAV3) is required for heart development in zebrafish.
Title: Neuron navigator 3 (NAV3) is required for heart development in zebrafish.
Morpholino-mediated knockdown of nav3a resulted in a significantly reduced liver size, and impaired development of pancreas and swim bladder.
Title: Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

z31441 (e-PCR), detects polymorphism
- UniSTS:238989

fk88h06.x1 (e-PCR)
- UniSTS:201671

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuron navigator 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045143.2 → NP_001038608.1 neuron navigator 3

See identical proteins and their annotated locations for NP_001038608.1

Status: PROVISIONAL

Source sequence(s)

BX511172, BX537169

UniProtKB/Swiss-Prot

Q5TZ18

Related

ENSDARP00000021413.7, ENSDART00000005847.9

Conserved Domains (5) summary

smart00382
Location:1960 → 2080

AAA; ATPases associated with a variety of cellular activities

PHA03249
Location:896 → 1055

PHA03249; DNA packaging tegument protein UL25; Provisional

cd00014
Location:59 → 160

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl21455
Location:1963 → 2054

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl23720
Location:1504 → 1575

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

20622794..20990445

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021475116.2 → XP_021330791.1 neuron navigator 3 isoform X17

UniProtKB/TrEMBL

A0A8M9PHH5

Conserved Domains (5) summary

smart00382
Location:2008 → 2128

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:21 → 125

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1507 → 1584

SH3_and_anchor; SH3 domain protein

cl25496
Location:1119 → 1442

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27999
Location:870 → 1029

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_021475117.2 → XP_021330792.1 neuron navigator 3 isoform X17

UniProtKB/TrEMBL

A0A8M9PHH5

Conserved Domains (5) summary

smart00382
Location:2008 → 2128

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:21 → 125

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1507 → 1584

SH3_and_anchor; SH3 domain protein

cl25496
Location:1119 → 1442

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27999
Location:870 → 1029

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_021475105.2 → XP_021330780.1 neuron navigator 3 isoform X1

UniProtKB/TrEMBL

A0A8M9QBF3

Conserved Domains (5) summary

smart00382
Location:2076 → 2196

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1575 → 1652

SH3_and_anchor; SH3 domain protein

cl25496
Location:1187 → 1510

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27999
Location:938 → 1097

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_021475107.2 → XP_021330782.1 neuron navigator 3 isoform X3

UniProtKB/TrEMBL

A0A8M9PHG5

Conserved Domains (5) summary

smart00382
Location:2076 → 2196

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1575 → 1652

SH3_and_anchor; SH3 domain protein

cl25496
Location:1187 → 1510

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27999
Location:938 → 1097

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_021475114.2 → XP_021330789.1 neuron navigator 3 isoform X11

UniProtKB/TrEMBL

A0A8M9Q0Q3

Conserved Domains (5) summary

smart00382
Location:2047 → 2167

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl25496
Location:1187 → 1510

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl25732
Location:1554 → 1848

SMC_N; RecF/RecN/SMC N terminal domain

cl27999
Location:938 → 1097

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_021475115.2 → XP_021330790.1 neuron navigator 3 isoform X12

UniProtKB/TrEMBL

A0A8M9QBG6

Conserved Domains (5) summary

smart00382
Location:2047 → 2167

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl25496
Location:1187 → 1510

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl25732
Location:1554 → 1848

SMC_N; RecF/RecN/SMC N terminal domain

cl27999
Location:938 → 1097

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_017355079.3 → XP_017210568.1 neuron navigator 3 isoform X4

UniProtKB/TrEMBL

A0A8M6YX31
XM_021475111.2 → XP_021330786.1 neuron navigator 3 isoform X8

UniProtKB/TrEMBL

A0A8M9Q614

Conserved Domains (6) summary

smart00382
Location:2061 → 2181

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1575 → 1652

SH3_and_anchor; SH3 domain protein

cl25496
Location:1187 → 1510

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl25732
Location:1565 → 1877

SMC_N; RecF/RecN/SMC N terminal domain

cl27999
Location:938 → 1097

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_068219723.1 → XP_068075824.1 neuron navigator 3 isoform X14
XM_009300421.4 → XP_009298696.1 neuron navigator 3 isoform X16

UniProtKB/TrEMBL

A0A8M3B919

Conserved Domains (5) summary

smart00382
Location:2032 → 2152

AAA; ATPases associated with a variety of cellular activities

PHA03249
Location:938 → 1097

PHA03249; DNA packaging tegument protein UL25; Provisional

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl21455
Location:2035 → 2126

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl23720
Location:1574 → 1646

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_021475106.2 → XP_021330781.1 neuron navigator 3 isoform X2

UniProtKB/TrEMBL

A0A8M9Q610

Conserved Domains (6) summary

smart00382
Location:2075 → 2195

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1575 → 1652

SH3_and_anchor; SH3 domain protein

cl25496
Location:1187 → 1510

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl25732
Location:1554 → 1876

SMC_N; RecF/RecN/SMC N terminal domain

cl27999
Location:938 → 1097

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_021475109.2 → XP_021330784.1 neuron navigator 3 isoform X6

UniProtKB/TrEMBL

A0A8M9Q0P5

Conserved Domains (5) summary

smart00382
Location:2068 → 2188

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1575 → 1652

SH3_and_anchor; SH3 domain protein

cl25496
Location:1187 → 1510

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27999
Location:938 → 1097

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_068219722.1 → XP_068075823.1 neuron navigator 3 isoform X13
XM_021475112.2 → XP_021330787.1 neuron navigator 3 isoform X9

UniProtKB/TrEMBL

A0A8M9PHG9

Conserved Domains (6) summary

smart00382
Location:2060 → 2180

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1575 → 1652

SH3_and_anchor; SH3 domain protein

cl25496
Location:1187 → 1510

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl25732
Location:1565 → 1876

SMC_N; RecF/RecN/SMC N terminal domain

cl27999
Location:938 → 1097

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_009300420.4 → XP_009298695.1 neuron navigator 3 isoform X15

UniProtKB/TrEMBL

A0A8M3ARI4

Conserved Domains (5) summary

smart00382
Location:2031 → 2151

AAA; ATPases associated with a variety of cellular activities

PHA03249
Location:938 → 1097

PHA03249; DNA packaging tegument protein UL25; Provisional

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl21455
Location:2034 → 2125

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl23720
Location:1574 → 1646

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_009300424.4 → XP_009298699.1 neuron navigator 3 isoform X21

UniProtKB/TrEMBL

A0A8M3ARS0

Conserved Domains (5) summary

smart00382
Location:2031 → 2151

AAA; ATPases associated with a variety of cellular activities

PHA03249
Location:938 → 1097

PHA03249; DNA packaging tegument protein UL25; Provisional

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl21455
Location:2034 → 2125

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl23720
Location:1574 → 1646

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_021475108.2 → XP_021330783.1 neuron navigator 3 isoform X5

UniProtKB/TrEMBL

A0A8M9PUP3

Conserved Domains (5) summary

smart00382
Location:2069 → 2189

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1568 → 1645

SH3_and_anchor; SH3 domain protein

cl25496
Location:1187 → 1510

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27999
Location:938 → 1097

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_021475110.2 → XP_021330785.1 neuron navigator 3 isoform X7

UniProtKB/TrEMBL

A0A8M9QBF8

Conserved Domains (4) summary

smart00382
Location:2067 → 2187

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1566 → 1643

SH3_and_anchor; SH3 domain protein

cl25496
Location:1178 → 1501

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_021475113.2 → XP_021330788.1 neuron navigator 3 isoform X10

UniProtKB/TrEMBL

A0A8M9PUQ1

Conserved Domains (5) summary

smart00382
Location:2053 → 2173

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:92 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1552 → 1629

SH3_and_anchor; SH3 domain protein

cl25496
Location:1164 → 1487

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27999
Location:915 → 1074

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
XM_021475118.2 → XP_021330793.1 neuron navigator 3 isoform X18

UniProtKB/TrEMBL

A0A8M9PUQ7

Conserved Domains (5) summary

smart00382
Location:1879 → 1999

AAA; ATPases associated with a variety of cellular activities

TIGR04211
Location:1378 → 1455

SH3_and_anchor; SH3 domain protein

cl25496
Location:990 → 1313

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27999
Location:741 → 900

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)

cl28482
Location:1848 → 1900

Pgk2; 2-phosphoglycerate kinase [Carbohydrate transport and metabolism]
XM_021475119.1 → XP_021330794.1 neuron navigator 3 isoform X19

UniProtKB/TrEMBL

A0A8M9Q0Q8

Conserved Domains (5) summary

smart00382
Location:1866 → 1986

AAA; ATPases associated with a variety of cellular activities

TIGR04211
Location:1365 → 1442

SH3_and_anchor; SH3 domain protein

cl25496
Location:977 → 1300

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl27999
Location:728 → 887

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)

cl28482
Location:1835 → 1887

Pgk2; 2-phosphoglycerate kinase [Carbohydrate transport and metabolism]
XM_021475120.2 → XP_021330795.1 neuron navigator 3 isoform X20

UniProtKB/TrEMBL

A0A8M9QBH1

Conserved Domains (6) summary

smart00382
Location:1582 → 1702

AAA; ATPases associated with a variety of cellular activities

cl25496
Location:693 → 1016

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl25732
Location:1060 → 1383

SMC_N; RecF/RecN/SMC N terminal domain

cl27403
Location:1061 → 1161

zf-RING_7; C4-type zinc ribbon domain

cl27999
Location:444 → 603

Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)

cl28482
Location:1551 → 1603

Pgk2; 2-phosphoglycerate kinase [Carbohydrate transport and metabolism]