runx1t1 RUNX1 partner transcriptional co-repressor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: runx1t1provided by ZNC
Official Full Name: RUNX1 partner transcriptional co-repressor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-164
See related: Ensembl:ENSDARG00000003680 AllianceGenome:ZFIN:ZDB-GENE-060929-164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MTG8; wu:fi14b07; zgc:154044; si:ch211-232j17.1
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within DNA-templated transcription. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human RUNX1T1 (RUNX1 partner transcriptional co-repressor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (33701539..33784485)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (34114353..34199584)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results found that runx1(W84X/W84X) mutation led to the reduction and disordering of B cells, as well as the failure of V(D)J rearrangements in B cells but not T cells, resulting in antibody-inadequate-mediated immunodeficiency. By contrast, T cell development was not affected. Furthermore, an evolutionarily conserved function of runx1 was demonstrated in maturation and differentiation of B cells in adult zebrafish.
Title: Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish.

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General gene information

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Markers

fj53h11.x1 (e-PCR)
- UniSTS:188675

G47600 (e-PCR)
- UniSTS:108374

fi14b07.x1 (e-PCR)
- UniSTS:196839

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein CBFA2T1

Names: RUNX1 translocation partner 1; runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076776.4 → NP_001070244.2 protein CBFA2T1

Status: VALIDATED

Source sequence(s)

CR735113, CR759910

UniProtKB/TrEMBL

A0A8M1NAX1, A0A8M6YUK0, Q1L8K2

Related

ENSDARP00000123046.2, ENSDART00000147226.4

Conserved Domains (4) summary

pfam01753
Location:497 → 533

zf-MYND; MYND finger

pfam07531
Location:102 → 188

TAFH; NHR1 homology to TAF

pfam08788
Location:319 → 385

NHR2; NHR2 domain like

cl23750
Location:423 → 479

vATP-synt_E; ATP synthase (E/31 kDa) subunit