insm1b insulinoma-associated 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: insm1bprovided by ZNC
Official Full Name: insulinoma-associated 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2602
See related: Ensembl:ENSDARG00000053301 AllianceGenome:ZFIN:ZDB-GENE-030131-2602
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Insm1; INSM-1; fc13a09; zINSM-1; zgc:63866; wu:fc13a09
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Predicted to be involved in several processes, including enteroendocrine cell differentiation; negative regulation of transcription by RNA polymerase II; and transdifferentiation. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in digestive system; midbrain neural keel; nervous system; olfactory field; and trigeminal placode. Orthologous to human INSM1 (INSM transcriptional repressor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 17

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (41463942..41466140)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (41475068..41477266)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development
Title: Expression of two insm1-like genes in the developing zebrafish nervous system.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc13a09.x1 (e-PCR)
- UniSTS:192606

fc13a09.x1 (e-PCR)
- UniSTS:192607

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pancreatic A cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle process	IBA Inferred from Biological aspect of Ancestor more info
involved_in transdifferentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in type B pancreatic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription repressor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: insulinoma-associated protein 1b

Names: insulinoma-associated 1-like protein b; zinc finger protein IA-1b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199658.1 → NP_955952.1 insulinoma-associated protein 1b

See identical proteins and their annotated locations for NP_955952.1

Status: PROVISIONAL

Source sequence(s)

BC053119

UniProtKB/Swiss-Prot

Q3S5C7, Q7T3H2

Related

ENSDARP00000069814.3, ENSDART00000075331.5

Conserved Domains (2) summary

sd00017
Location:226 → 246

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:321 → 343

zf-C2H2; Zinc finger, C2H2 type