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    herc2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 558479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    herc2provided by ZNC
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070718-6
    See related
    Ensembl:ENSDARG00000073841 AllianceGenome:ZFIN:ZDB-GENE-070718-6
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd13h10; wu:fd13h10
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 38 and pigmentation disease. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See herc2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    93
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (37752778..37848607)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (37774863..37871075)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene NIPA magnesium transporter 2 Neighboring gene NIPA magnesium transporter 1 Neighboring gene oculocutaneous albinism II Neighboring gene uncharacterized LOC137495992 Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma3 Neighboring gene uncharacterized LOC137495993

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Recent assembly of an imprinted domain from non-imprinted components. Rapkins RW, et al. PLoS Genet, 2006 Oct. PMID 17069464, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HERC2
    Names
    hect domain and RLD 2
    XP_021327484.2
    XP_021332871.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      37752778..37848607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477196.2 → XP_021332871.1  E3 ubiquitin-protein ligase HERC2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QB68, A0A8M9QG78
      Related
      ENSDARP00000098322.3, ENSDART00000110770.4
      Conserved Domains (8) summary
      cd08664
      Location:2759 → 2902
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      cd00078
      Location:4417 → 4788
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2700 → 2744
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2453 → 2499
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1204 → 1276
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam06701
      Location:1862 → 1920
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2548 → 2625
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl27697
      Location:2946 → 3316
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394658.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      73..34903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471809.2 → XP_021327484.2  E3 ubiquitin-protein ligase HERC2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PRI1
    Nucleotide Protein Strain
    Heading Accession and Version

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