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    spint1b serine peptidase inhibitor, Kunitz type 1 b [ Danio rerio (zebrafish) ]

    Gene ID: 797346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spint1bprovided by ZNC
    Official Full Name
    serine peptidase inhibitor, Kunitz type 1 bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071218-1
    See related
    Ensembl:ENSDARG00000012467 AllianceGenome:ZFIN:ZDB-GENE-071218-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within epidermis development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in gut; lateral line primordium; and primitive olfactory epithelium. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spint1b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (3218893..3238079, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (3201392..3220578, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 170Bb Neighboring gene si:ch73-212j7.3 Neighboring gene ribosomal protein S6 kinase polypeptide 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Skin exposure to micro- and nano-particles can cause haemostasis in zebrafish larvae. McLeish JA, et al. Thromb Haemost, 2010 Apr. PMID 20174755
    2. Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Carney TJ, et al. Development, 2007 Oct. PMID 17728346
    3. Met and Hgf signaling controls hypaxial muscle and lateral line development in the zebrafish. Haines L, et al. Development, 2004 Oct. PMID 15342468
    4. Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation. Karampelias C, et al. Nat Commun, 2021 Jun 7. PMID 34099692, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epidermis development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within epidermis development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epithelium development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kunitz-type protease inhibitor 1b
    Names
    hai1b
    hepatocyte growth factor activator inhibitor 1
    hepatocyte growth factor activator inhibitor 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111223.1 → NP_001104693.1  kunitz-type protease inhibitor 1b precursor

      See identical proteins and their annotated locations for NP_001104693.1

      Status: PROVISIONAL

      Source sequence(s)
      BC155551
      UniProtKB/TrEMBL
      A9JR82
      Related
      ENSDARP00000006108.7, ENSDART00000008077.9
      Conserved Domains (4) summary
      smart00089
      Location:148 → 225
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      cd00112
      Location:308 → 342
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00014
      Location:363 → 413
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam07502
      Location:31 → 116
      MANEC; MANEC domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      3218893..3238079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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