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    dpf2l D4, zinc and double PHD fingers family 2, like [ Danio rerio (zebrafish) ]

    Gene ID: 326933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpf2lprovided by ZNC
    Official Full Name
    D4, zinc and double PHD fingers family 2, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5132
    See related
    Ensembl:ENSDARG00000037291 AllianceGenome:ZFIN:ZDB-GENE-030131-5132
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    REQ; Dpf2; wu:fe50b03; zgc:110767
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 7. Orthologous to human DPF2 (double PHD fingers 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dpf2l in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (24267897..24277354, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (23970652..23980109, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene BCL2 interacting protein 1a Neighboring gene cholinergic receptor, muscarinic 1a Neighboring gene uncharacterized LOC107195253 Neighboring gene heterogeneous nuclear ribonucleoprotein A0a Neighboring gene kelch-like family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gene loss and evolutionary rates following whole-genome duplication in teleost fishes. Brunet FG, et al. Mol Biol Evol, 2006 Sep. PMID 16809621
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110767

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nBAF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D4, zinc and double PHD fingers family 2, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212696.2 → NP_997861.2  D4, zinc and double PHD fingers family 2, like

      See identical proteins and their annotated locations for NP_997861.2

      Status: PROVISIONAL

      Source sequence(s)
      BC092130
      UniProtKB/TrEMBL
      A0A0R4IYI6, A0A8N7XJ24, B2GT78, Q58E00
      Related
      ENSDARP00000054242.4, ENSDART00000054243.5
      Conserved Domains (4) summary
      cl02553
      Location:222 → 244
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cd15530
      Location:341 → 386
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15691
      Location:284 → 339
      PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
      pfam14051
      Location:13 → 79
      Requiem_N; N-terminal domain of DPF2/REQ

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      24267897..24277354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394909.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      236273..245658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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