flot2a flotillin 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: flot2aprovided by ZNC
Official Full Name: flotillin 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020430-3
See related: Ensembl:ENSDARG00000004830 AllianceGenome:ZFIN:ZDB-GENE-020430-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb48a04; zgc:55821; im:7143869; wu:fb48a04
Summary: Predicted to enable protease binding activity. Acts upstream of or within regulation of cell-cell adhesion mediated by cadherin and regulation of epiboly involved in gastrulation with mouth forming second. Predicted to be located in endocytic vesicle and endosome. Predicted to be part of flotillin complex. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including fin; nervous system; pectoral fin bud; segmental plate; and trigeminal placode. Orthologous to human FLOT2 (flotillin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (42834042..42872712, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (42233889..42272561, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results provide the first in vivo evidence that Flotillins regulate E-cadherin-mediated cell-cell junctions to allow epiboly progression.
Title: Flotillins control zebrafish epiboly through their role in cadherin-mediated cell-cell adhesion.
Analysis of reggie mRNA and protein expression patterns during early zebrafish development revealed re-2a can be observed in differentiating neurons in the brain, spinal cord, and neurogenic placodes.
Title: Restricted expression of reggie genes and proteins during early zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Markers

AI497174 (e-PCR)
- UniSTS:206363

fc56d03.y1 (e-PCR)
- UniSTS:194085

fc48f10 (e-PCR)
- UniSTS:189233

fc29d08.y1 (e-PCR)
- UniSTS:193448

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of epiboly involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
part_of flotillin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: flotillin-2a

Names: REG-1; reggie-1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213075.2 → NP_998240.2 flotillin-2a

See identical proteins and their annotated locations for NP_998240.2

Status: VALIDATED

Source sequence(s)

AW174527, BC165232, BX323596, EB834549, EB850170, EB909858

UniProtKB/Swiss-Prot

B5DDN8, Q803F9, Q98TZ8

Related

ENSDARP00000011656.4, ENSDART00000003947.6

Conserved Domains (4) summary

smart00244
Location:87 → 268

PHB; prohibitin homologues

cd03399
Location:34 → 178

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

pfam15975
Location:312 → 396

Flot; Flotillin

cl19107
Location:260 → 347

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

42834042..42872712 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301623.4 → XP_009299898.1 flotillin-2a isoform X2

UniProtKB/TrEMBL

A0A8M3B9S2

Conserved Domains (4) summary

smart00244
Location:22 → 203

PHB; prohibitin homologues

cd03399
Location:10 → 113

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

pfam15975
Location:247 → 323

Flot; Flotillin

cl19107
Location:195 → 282

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
XM_005165263.5 → XP_005165320.1 flotillin-2a isoform X1

UniProtKB/TrEMBL

A0A8M2BCI4

Conserved Domains (4) summary

smart00244
Location:87 → 268

PHB; prohibitin homologues

cd03399
Location:34 → 178

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

pfam15975
Location:312 → 396

Flot; Flotillin

cl19107
Location:260 → 347

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily