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    nrg2a neuregulin 2a [ Danio rerio (zebrafish) ]

    Gene ID: 100006951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nrg2aprovided by ZNC
    Official Full Name
    neuregulin 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070615-10
    See related
    Ensembl:ENSDARG00000077818 AllianceGenome:ZFIN:ZDB-GENE-070615-10
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162973
    Summary
    Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including heart trabecula morphogenesis; neural crest cell migration; and peripheral nervous system development. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in brain; epidermis; heart; median fin fold; and somite. Orthologous to human NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nrg2a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (28554289..28737337, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (28517601..28700709, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1a Neighboring gene ependymin-like 2 Neighboring gene zgc:100829 Neighboring gene purine-rich element binding protein Aa Neighboring gene uncharacterized LOC137488867

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish. Abdul-Wajid S, et al. Nat Commun, 2018 Nov 2. PMID 30389937, Free PMC Article
    2. Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. Qi J, et al. Elife, 2022 Feb 28. PMID 35225788, Free PMC Article
    3. In vivo analysis of cardiomyocyte proliferation during trabeculation. Uribe V, et al. Development, 2018 Jul 30. PMID 30061167
    4. Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling. Rasouli SJ, et al. Nat Commun, 2017 May 9. PMID 28485381, Free PMC Article
    5. Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons. Honjo Y, et al. Development, 2008 Aug. PMID 18599505, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. zebrafish Nrg2a is required for trabeculation.
      Title: Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling.
    2. Embryos homozygous for a GBT insertion within neuregulin 2a (nrg2a) revealed a novel requirement for a Neuregulin 2a (Nrg2a)-ErbB2/3-AKT signaling pathway governing the organization of a subset of epidermal cells during median fin fold morphogenesis.
      Title: Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis.
    3. ErbB3 signaling is required for normal migration of trunk, but not cranial, neural crest cells[Neuregulin 2]
      Title: Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart trabecula formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neural crest cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skin epidermis development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skin epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuregulin 2a
    Names
    nrg2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099254.2 → NP_001092724.1  neuregulin 2a isoform 2

      See identical proteins and their annotated locations for NP_001092724.1

      Status: VALIDATED

      Source sequence(s)
      BX511240, CR751225
      UniProtKB/TrEMBL
      A0A8M1NDH0, A0A8M3AMA6, A5D6U9
      Related
      ENSDARP00000089467.4, ENSDART00000098696.6
      Conserved Domains (4) summary
      smart00410
      Location:4 → 85
      IG_like; Immunoglobulin like
      cd00054
      Location:110 → 138
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02158
      Location:155 → 476
      Neuregulin; Neuregulin family
      cl11960
      Location:13 → 83
      Ig; Immunoglobulin domain

    2. NM_001430844.1 → NP_001417773.1  neuregulin 2a isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CR751225, CT573432
      UniProtKB/TrEMBL
      A0A8M2B890, A0A8M3AMA6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      28554289..28737337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215752.1 → XP_068071853.1  neuregulin 2a isoform X11

      UniProtKB/TrEMBL
      A0A8M3AMA6
      Related
      ENSDARP00000109319.1, ENSDART00000128237.3

    2. XM_068215751.1 → XP_068071852.1  neuregulin 2a isoform X10

      UniProtKB/TrEMBL
      A0A8M3AMA6

    3. XM_068215753.1 → XP_068071854.1  neuregulin 2a isoform X12

      UniProtKB/TrEMBL
      A0A8M3AMA6

    4. XM_068215749.1 → XP_068071850.1  neuregulin 2a isoform X8

      UniProtKB/TrEMBL
      A0A8M3AMA6

    5. XM_068215750.1 → XP_068071851.1  neuregulin 2a isoform X9

      UniProtKB/TrEMBL
      A0A8M3AMA6

    6. XM_068215748.1 → XP_068071849.1  neuregulin 2a isoform X5

    7. XM_009295459.4 → XP_009293734.1  neuregulin 2a isoform X3

      UniProtKB/TrEMBL
      A0A8M3ATZ5
      Conserved Domains (4) summary
      cd05750
      Location:158 → 228
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
      PHA03099
      Location:220 → 294
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00410
      Location:149 → 230
      IG_like; Immunoglobulin like
      pfam02158
      Location:302 → 627
      Neuregulin; Neuregulin family

    8. XM_005161327.5 → XP_005161384.1  neuregulin 2a isoform X6

      UniProtKB/TrEMBL
      A0A8M2B897
      Conserved Domains (4) summary
      cd05750
      Location:158 → 228
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
      smart00410
      Location:149 → 230
      IG_like; Immunoglobulin like
      cd00054
      Location:255 → 283
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02158
      Location:300 → 621
      Neuregulin; Neuregulin family

    9. XM_009295460.4 → XP_009293735.1  neuregulin 2a isoform X4

      UniProtKB/TrEMBL
      A0A8M3ALK5
      Conserved Domains (4) summary
      cd05750
      Location:158 → 228
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
      smart00410
      Location:149 → 230
      IG_like; Immunoglobulin like
      pfam02158
      Location:300 → 625
      Neuregulin; Neuregulin family
      pfam07974
      Location:250 → 283
      EGF_2; EGF-like domain

    10. XM_068215747.1 → XP_068071848.1  neuregulin 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M3AMA6

    11. XM_009295461.4 → XP_009293736.1  neuregulin 2a isoform X7

      UniProtKB/TrEMBL
      A0A8M3AMA6, A0A8M3B4T6
      Conserved Domains (4) summary
      cd05750
      Location:50 → 120
      Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
      PHA03099
      Location:112 → 186
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00410
      Location:41 → 122
      IG_like; Immunoglobulin like
      pfam02158
      Location:194 → 594
      Neuregulin; Neuregulin family

    12. XM_021468743.2 → XP_021324418.1  neuregulin 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PCF9
      Conserved Domains (2) summary
      pfam02158
      Location:232 → 632
      Neuregulin; Neuregulin family
      cl28647
      Location:175 → 224
      PHA02887; EGF-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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