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    usp19 ubiquitin specific peptidase 19 [ Danio rerio (zebrafish) ]

    Gene ID: 324335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    usp19provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 19provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3055
    See related
    Ensembl:ENSDARG00000004132 AllianceGenome:ZFIN:ZDB-GENE-030131-3055
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc26a05; si:dkey-32e6.9
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and metal ion binding activity. Acts upstream of or within central nervous system morphogenesis. Predicted to be located in membrane. Orthologous to human USP19 (ubiquitin specific peptidase 19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See usp19 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20145141..20177559, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20218798..20251234, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkey-32e6.3 Neighboring gene leucine rich repeat containing 23 Neighboring gene laminin, beta 2 (laminin S) Neighboring gene laminin, beta 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). Zhao N, et al. Int J Mol Sci, 2022 Sep 10. PMID 36142434, Free PMC Article
    2. A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. Tiefenbach J, et al. PLoS One, 2010 Mar 22. PMID 20339547, Free PMC Article
    3. What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. Cheung CT, et al. BMC Genomics, 2019 Jul 15. PMID 31307377, Free PMC Article
    4. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 19
    XP_005162175.1
    XP_005162176.1
    XP_005162177.1
    XP_068072993.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      20145141..20177559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216892.1 → XP_068072993.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X4

      UniProtKB/TrEMBL
      A0A8M9P5F2

    2. XM_005162120.5 → XP_005162177.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B8Y4, A0A8M9P5F2, F1RCS0
      Related
      ENSDARP00000100933.2, ENSDART00000112840.5
      Conserved Domains (7) summary
      cd06463
      Location:59 → 140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:427 → 523
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:1197 → 1360
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:639 → 825
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:932 → 974
      zf-MYND; MYND finger
      pfam14533
      Location:809 → 900
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:514 → 636
      USP19_linker; Linker region of USP19 deubiquitinase

    3. XM_005162119.5 → XP_005162176.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B8X8, A0A8M9P5F2
      Conserved Domains (7) summary
      cd06463
      Location:59 → 140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:427 → 523
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:1195 → 1358
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:637 → 823
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:930 → 972
      zf-MYND; MYND finger
      pfam14533
      Location:807 → 898
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:514 → 634
      USP19_linker; Linker region of USP19 deubiquitinase

    4. XM_005162118.5 → XP_005162175.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B997, A0A8M9P5F2
      Related
      ENSDARP00000116060.1, ENSDART00000147778.2
      Conserved Domains (7) summary
      cd06463
      Location:59 → 140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:427 → 523
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:1197 → 1360
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:639 → 825
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:932 → 974
      zf-MYND; MYND finger
      pfam14533
      Location:809 → 900
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:514 → 636
      USP19_linker; Linker region of USP19 deubiquitinase
    Nucleotide Protein Strain
    Heading Accession and Version

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