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    gab1 GRB2-associated binding protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406666, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gab1provided by ZNC
    Official Full Name
    GRB2-associated binding protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2674
    See related
    Ensembl:ENSDARG00000037018 AllianceGenome:ZFIN:ZDB-GENE-040426-2674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb11b01; fc66d01; zgc:56412; wu:fb11b01; wu:fc66d01
    Summary
    Predicted to enable signaling adaptor activity. Acts upstream of or within epiboly. Predicted to be active in cytoplasm. Is expressed in brain; heart; inner ear; and swim bladder. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gab1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (35494785..35609659)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (34762673..34877632)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495583 Neighboring gene ubiquitin specific peptidase 38 Neighboring gene Fras1 related extracellular matrix 3 Neighboring gene si:dkey-27h10.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. Yousaf R, et al. J Clin Invest, 2018 Apr 2. PMID 29408807, Free PMC Article
    2. New Insights into the Identity of the DFNA58 Gene. Nascimento LRD, et al. Genes (Basel), 2022 Dec 2. PMID 36553541, Free PMC Article
    3. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Wang L, et al. Development, 2013 Jul. PMID 23698347
    4. An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. Postlethwait JH, et al. bioRxiv, 2020 Sep 2. PMID 32908984, Free PMC Article
    5. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within epiboly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    GRB2-associated-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326713.1 → NP_001313642.1  GRB2-associated-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      BX322570, CR388194, FP236452
      UniProtKB/TrEMBL
      A0A8M1P8X5, F1Q7S5
      Related
      ENSDARP00000116730.2, ENSDART00000140724.4
      Conserved Domains (2) summary
      cd01266
      Location:3 → 125
      PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain
      pfam00169
      Location:6 → 115
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      35494785..35609659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353102.3 → XP_017208591.1  GRB2-associated-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YUV9

    2. XM_021469872.2 → XP_021325547.1  GRB2-associated-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P5A1
      Conserved Domains (1) summary
      cd01266
      Location:3 → 125
      PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain

    3. XM_017353106.3 → XP_017208595.1  GRB2-associated-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YVD8

    4. XM_021469911.2 → XP_021325586.1  GRB2-associated-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PTD5
      Conserved Domains (1) summary
      cd01266
      Location:3 → 125
      PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain

    5. XM_009292494.4 → XP_009290769.1  GRB2-associated-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AJA8, F6NTT0
      Related
      ENSDARP00000053805.7, ENSDART00000053806.7
      Conserved Domains (2) summary
      cd01266
      Location:3 → 125
      PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain
      pfam00169
      Location:6 → 115
      PH; PH domain

    6. XM_068216453.1 → XP_068072554.1  GRB2-associated-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PWZ6

    7. XM_021470020.2 → XP_021325695.1  GRB2-associated-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PWZ6
      Conserved Domains (1) summary
      cl17171
      Location:1 → 22
      PH-like; Pleckstrin homology-like domain

    8. XM_068216509.1 → XP_068072610.1  GRB2-associated-binding protein 1 isoform X7

    9. XM_021469996.2 → XP_021325671.1  GRB2-associated-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PWZ6
      Conserved Domains (1) summary
      cl17171
      Location:1 → 22
      PH-like; Pleckstrin homology-like domain

    10. XM_021469965.2 → XP_021325640.1  GRB2-associated-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PWZ6
      Conserved Domains (1) summary
      cl17171
      Location:1 → 22
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_002456597.2 RNA Sequence

    2. XR_002456601.2 RNA Sequence

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394497.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      5668..17805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395221.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      5668..17805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_213357.1: Suppressed sequence

      Description
      NM_213357.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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