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    pak2a p21 protein (Cdc42/Rac)-activated kinase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 266749, updated on 9-Dec-2024

    Summary

    Official Symbol
    pak2aprovided by ZNC
    Official Full Name
    p21 protein (Cdc42/Rac)-activated kinase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021011-2
    See related
    Ensembl:ENSDARG00000068177 AllianceGenome:ZFIN:ZDB-GENE-021011-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pak2; cb422; kinase; zgc:91798; wu:fb71h01; si:dz198m22.1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development. Predicted to be active in cytoplasm. Is expressed in several structures, including Kupffer's vesicle; axial mesoderm; axial vasculature; axis; and central nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See pak2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (36609099..36636869)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (36626447..36654414)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886155 Neighboring gene inhibitor of growth family, member 5b Neighboring gene kelch-like family member 6 Neighboring gene cyclin L1b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase PAK 2a
    Names
    p21 (CDKN1A)-activated kinase 2
    p21 (CDKN1A)-activated kinase 2a
    p21-activated kinase 2
    redhead
    rhd
    NP_001002717.1
    XP_005171319.1
    XP_005171320.1
    XP_068078998.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002717.1NP_001002717.1  serine/threonine-protein kinase PAK 2a

      See identical proteins and their annotated locations for NP_001002717.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076511
      UniProtKB/TrEMBL
      A0A0R4IQG0, A0A8N7XJE5, B2GRT8, Q6DG42
      Related
      ENSDARP00000089188.2, ENSDART00000098417.3
      Conserved Domains (3) summary
      cd06655
      Location:222517
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:242493
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:74129
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      36609099..36636869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171263.5XP_005171320.1  serine/threonine-protein kinase PAK 2a isoform X1

      See identical proteins and their annotated locations for XP_005171320.1

      UniProtKB/TrEMBL
      A0A0R4IQG0, A0A8N7XJE5, B2GRT8, Q6DG42
      Conserved Domains (3) summary
      cd06655
      Location:222517
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:242493
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:74129
      PBD; P21-Rho-binding domain
    2. XM_005171262.5XP_005171319.1  serine/threonine-protein kinase PAK 2a isoform X1

      See identical proteins and their annotated locations for XP_005171319.1

      UniProtKB/TrEMBL
      A0A0R4IQG0, A0A8N7XJE5, B2GRT8, Q6DG42
      Related
      ENSDARP00000137659.2, ENSDART00000159541.2
      Conserved Domains (3) summary
      cd06655
      Location:222517
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:242493
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:74129
      PBD; P21-Rho-binding domain
    3. XM_068222897.1XP_068078998.1  serine/threonine-protein kinase PAK 2a isoform X2