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    aqr aquarius intron-binding spliceosomal factor [ Danio rerio (zebrafish) ]

    Gene ID: 393436, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aqrprovided by ZNC
    Official Full Name
    aquarius intron-binding spliceosomal factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1189
    See related
    Ensembl:ENSDARG00000016775 AllianceGenome:ZFIN:ZDB-GENE-040426-1189
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63611
    Summary
    Predicted to enable mRNA binding activity. Predicted to act upstream of or within mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See aqr in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (51020024..51121771, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (50931126..51032873, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100537702 Neighboring gene uncharacterized LOC103909099 Neighboring gene papilin a, proteoglycan-like sulfated glycoprotein Neighboring gene presenilin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein. Sztal TE, et al. PLoS Genet, 2018 Feb. PMID 29420541, Free PMC Article
    2. Processing of fish Ig heavy chain transcripts: diverse splicing patterns and unusual nonsense mediated decay. Quiniou SM, et al. Dev Comp Immunol, 2011 Sep. PMID 21168434
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC63611

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA helicase aquarius
    Names
    aquarius homolog
    NP_956758.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200464.2 → NP_956758.2  RNA helicase aquarius

      See identical proteins and their annotated locations for NP_956758.2

      Status: PROVISIONAL

      Source sequence(s)
      BC160661
      UniProtKB/TrEMBL
      B1H1M2
      Related
      ENSDARP00000110866.3, ENSDART00000130412.3
      Conserved Domains (5) summary
      pfam05466
      Location:1400 → 1525
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam13086
      Location:800 → 1106
      AAA_11; AAA domain
      pfam13245
      Location:807 → 879
      AAA_19; Part of AAA domain
      pfam16399
      Location:18 → 801
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:1114 → 1303
      UvrD_C_2; UvrD-like helicase C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      51020024..51121771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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