selenon selenoprotein N [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: selenonprovided by ZNC
Official Full Name: selenoprotein Nprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030327-7
See related: Ensembl:ENSDARG00000033616 AllianceGenome:ZFIN:ZDB-GENE-030327-7
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SePN; selN; cb686; sepn1; wu:fb06g01; wu:fb73d02; wu:fv41b08; zgc:101091
Summary: This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in the orthologous gene in human are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. Inhibition of this gene in zebrafish also showed the importance of this gene in muscle organization during early development. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. [provided by RefSeq, Aug 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (24687338..24695198)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (24668937..24676797)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sepn1 and ryr1 are required for the same cellular differentiation events and are needed for normal calcium fluxes
Title: Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle.
alteration of myofibril architecture and tendon-like structure in embryos deficient for SelN function provide new insights into the pathological mechanism of SelN-related myopathy
Title: Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo.

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General gene information

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Markers

fb73d02 (e-PCR)
- UniSTS:187435

fb06g01.x1 (e-PCR)
- UniSTS:189920

fb06g01.x1 (e-PCR)
- UniSTS:189921

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ryanodine-sensitive calcium-release channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle fiber development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: selenoprotein N

Names: selenoprotein N, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.