spoplb speckle type BTB/POZ protein like b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spoplbprovided by ZNC
Official Full Name: speckle type BTB/POZ protein like bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061103-277
See related: Ensembl:ENSDARG00000003974 AllianceGenome:ZFIN:ZDB-GENE-061103-277
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6961637; zgc:153365
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of proteolysis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (33818302..33842711)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (33555500..33579909)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: speckle-type POZ protein-like B

Names: HIB homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079969.1 → NP_001073438.1 speckle-type POZ protein-like B

See identical proteins and their annotated locations for NP_001073438.1

Status: PROVISIONAL

Source sequence(s)

BC125865

UniProtKB/Swiss-Prot

A0JMG1

Related

ENSDARP00000103804.3, ENSDART00000109418.5

Conserved Domains (4) summary

smart00225
Location:189 → 285

BTB; Broad-Complex, Tramtrack and Bric a brac

cd14734
Location:285 → 365

SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:178 → 282

BTB; BTB/POZ domain

cl02446
Location:16 → 154

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...