nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nr3c1provided by ZNC
Official Full Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-503
See related: Ensembl:ENSDARG00000025032 AllianceGenome:ZFIN:ZDB-GENE-050522-503
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gr; utut; utouto; fb13f09; wu:fb13f09; zgc:113038
Summary: Enables nuclear glucocorticoid receptor activity. Acts upstream of or within several processes, including chondrocyte proliferation; monoatomic cation transport; and response to glucocorticoid. Located in cytoplasm and nucleus. Is expressed in several structures, including blastodisc; digestive system; eye; gill; and pleuroperitoneal region. Used to study depressive disorder and generalized anxiety disorder. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (23747183..23801389, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (23449938..23504144, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain.
Title: Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain.
Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription.
Title: Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription.
The role of the Glucocorticoid Receptor in the Regulation of Diel Rhythmicity.
Title: The role of the Glucocorticoid Receptor in the Regulation of Diel Rhythmicity.
Knockout of the Glucocorticoid Receptor Impairs Reproduction in Female Zebrafish.
Title: Knockout of the Glucocorticoid Receptor Impairs Reproduction in Female Zebrafish.
Glucocorticoid and mineralocorticoid receptor activation modulates postnatal growth.
Title: Glucocorticoid and mineralocorticoid receptor activation modulates postnatal growth.
Feeding Entrainment of the Zebrafish Circadian Clock Is Regulated by the Glucocorticoid Receptor.
Title: Feeding Entrainment of the Zebrafish Circadian Clock Is Regulated by the Glucocorticoid Receptor.
Chronic stressor-mediated GR signaling limits muscle glucose uptake, and this may play a role in protein catabolism, leading to the growth suppression in fish.
Title: Loss of the glucocorticoid receptor in zebrafish improves muscle glucose availability and increases growth.
Opn4m2 labeling shows nuclear localization, which did not change in response to light. opn4m1, opn4m2, gr, per1b, and cry1b presented an oscillatory profile of expression in LD condition. In both DD and LD condition, dexamethasone (DEX) treatment shifted the peak expression of per1b and cry1b transcripts
Title: Dexamethasone Modulates Nonvisual Opsins, Glucocorticoid Receptor, and Clock Genes in Danio rerio ZEM-2S Cells.
GR agonists enhanced, whereas GR loss diminished, Hematopoietic stem and progenitor cell formation.
Title: The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling.
Two distinct gene clusters were found that were regulated by GRalpha: one that was regulated by GRalpha under basal conditions (presence of endogenous cortisol only), and one that was regulated upon increased activation of GRalpha.
Title: Transcriptional and metabolic effects of glucocorticoid receptor α and β signaling in zebrafish.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear glucocorticoid receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to cortisol stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circadian behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucocorticoid mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within light adaption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within nuclear receptor-mediated glucocorticoid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of hypoxia-inducible factor-1alpha signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proton export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to cortisol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to cortisol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to dexamethasone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to glucocorticoid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucocorticoid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020711.3 → NP_001018547.2 glucocorticoid receptor

See identical proteins and their annotated locations for NP_001018547.2

Status: VALIDATED

Source sequence(s)

BX470157

UniProtKB/TrEMBL

A6YIH6, Q1XHK0

Related

ENSDARP00000054263.3, ENSDART00000054264.5

Conserved Domains (3) summary

cd06947
Location:500 → 744

NR_LBD_GR_Like; Ligand binding domain of nuclear hormone receptors:glucocorticoid receptor, mineralocorticoid receptor , progesterone receptor, and androgen receptor

cd07172
Location:383 → 460

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:18 → 369

GCR; Glucocorticoid receptor