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    naalad2 N-acetylated alpha-linked acidic dipeptidase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 393247, updated on 9-Dec-2024

    Summary

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    Official Symbol
    naalad2provided by ZNC
    Official Full Name
    N-acetylated alpha-linked acidic dipeptidase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1025
    See related
    Ensembl:ENSDARG00000021383 AllianceGenome:ZFIN:ZDB-GENE-040426-1025
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56429
    Summary
    Predicted to enable carboxypeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in plasma membrane. Is expressed in epidermis; nervous system; otic vesicle; periderm; and pronephros. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See naalad2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (43895797..43942068)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (43882600..43918625)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene tyrosinase Neighboring gene NADPH oxidase 4 Neighboring gene uncharacterized LOC100333163 Neighboring gene uncharacterized LOC137487792 Neighboring gene uncharacterized LOC101885254 Neighboring gene uncharacterized LOC103908875

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. In silico and biological analysis of anti-androgen activity of the brominated flame retardants ATE, BATE and DPTE in zebrafish. Pradhan A, et al. Chem Biol Interact, 2015 May 25. PMID 25818047
    2. Nox4 promotes osteoblast differentiation through TGF-beta signal pathway. Cao Z, et al. Free Radic Biol Med, 2022 Nov 20. PMID 36372285
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC56429

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylated-alpha-linked acidic dipeptidase 2
    Names
    glutamate carboxypeptidase 2-like
    NP_956571.1
    XP_009290230.3
    XP_068069584.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200277.1 → NP_956571.1  N-acetylated-alpha-linked acidic dipeptidase 2

      See identical proteins and their annotated locations for NP_956571.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049312
      UniProtKB/TrEMBL
      Q7ZUD9
      Related
      ENSDARP00000016784.5, ENSDART00000010881.7
      Conserved Domains (4) summary
      cd08022
      Location:341 → 581
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:108 → 333
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:618 → 733
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:47 → 102
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      43895797..43942068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213483.1 → XP_068069584.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

    2. XM_009291955.4 → XP_009290230.3  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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