U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    nr2f1a nuclear receptor subfamily 2, group F, member 1a [ Danio rerio (zebrafish) ]

    Gene ID: 30418, updated on 9-Dec-2024

    Summary

    Official Symbol
    nr2f1aprovided by ZNC
    Official Full Name
    nuclear receptor subfamily 2, group F, member 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-115
    See related
    Ensembl:ENSDARG00000052695 AllianceGenome:ZFIN:ZDB-GENE-980526-115
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nr2f1; svp44; couptf6; COUP(VI); wu:fc10d05
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Acts upstream of or within circulatory system development and endothelial cell proliferation. Predicted to be located in nucleus. Is expressed in several structures, including basal plate midbrain region; cardiovascular system; mesoderm; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Bosch-Boonstra-Schaaf optic atrophy syndrome. Orthologous to human NR2F1 (nuclear receptor subfamily 2 group F member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See nr2f1a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (49744782..49751528)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (49093181..49100020)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110439827 Neighboring gene uncharacterized LOC137495630 Neighboring gene lincRNA gene 0464 Neighboring gene ARB2 cotranscriptional regulator A Neighboring gene si:ch73-280o22.2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription factor activity  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables metal ion binding  
    enables nuclear receptor activity  
    enables sequence-specific DNA binding  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in nucleus  

    General protein information

    Preferred Names
    nuclear receptor subfamily 2 group F member 1-A
    Names
    COUP transcription factor 1-A
    COUP-TFalpha-A
    COUPTFalpha-A
    etID309751.5
    nuclear receptor subfamily 2, group F, member 1
    seven-up related 44
    steroid receptor homolog SVP 44
    svp[44]
    zCOUP-TFI
    zSvp[44]

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131180.1 → NP_571255.1  nuclear receptor subfamily 2 group F member 1-A

      See identical proteins and their annotated locations for NP_571255.1

      Status: PROVISIONAL

      Source sequence(s)
      X70299
      UniProtKB/Swiss-Prot
      A2CEQ1, O42536, Q06725, Q6PHF2
      Related
      ENSDARP00000116750.2, ENSDART00000133384.3
      Conserved Domains (3) summary
      cd06948
      Location:174 → 409
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
      cd06958
      Location:76 → 148
      NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
      NF033761
      Location:11 → 59
      gliding_GltJ; adventurous gliding motility protein GltJ

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      49744782..49751528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.