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    tbrg1 transforming growth factor beta regulator 1 [ Danio rerio (zebrafish) ]

    Gene ID: 573117, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbrg1provided by ZNC
    Official Full Name
    transforming growth factor beta regulator 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080220-62
    See related
    Ensembl:ENSDARG00000074996 AllianceGenome:ZFIN:ZDB-GENE-080220-62
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:171428
    Summary
    Predicted to be involved in regulation of cell cycle. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human TBRG1 (transforming growth factor beta regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tbrg1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (35228872..35254027)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (35254269..35276576)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene si:ch211-195m9.3 Neighboring gene cilia and flagella associated protein 45 Neighboring gene protein jagged-1b Neighboring gene uncharacterized LOC137488314 Neighboring gene small nuclear ribonucleoprotein polypeptide A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transforming growth factor beta regulator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114446.1 → NP_001107918.2  transforming growth factor beta regulator 1

      Status: PROVISIONAL

      Source sequence(s)
      BC155063
      UniProtKB/TrEMBL
      A0A8M1NHI5, A9JST2
      Related
      ENSDARP00000105690.1, ENSDART00000129624.3
      Conserved Domains (3) summary
      pfam05066
      Location:52 → 118
      HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain
      pfam05964
      Location:330 → 379
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:385 → 460
      FYRC; F/Y rich C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      35228872..35254027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467700.2 → XP_021323375.1  transforming growth factor beta regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQD4, A9JST2
      Conserved Domains (3) summary
      pfam05066
      Location:52 → 103
      HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain
      pfam05964
      Location:308 → 358
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:364 → 445
      FYRC; F/Y rich C-terminus

    2. XM_009293772.4 → XP_009292047.1  transforming growth factor beta regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AJR4, A9JST2
      Conserved Domains (2) summary
      pfam05964
      Location:236 → 285
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:291 → 366
      FYRC; F/Y rich C-terminus

    RNA

    1. XR_011007164.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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