dennd2db DENN/MADD domain containing 2Db [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dennd2dbprovided by ZNC
Official Full Name: DENN/MADD domain containing 2Dbprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-34
See related: Ensembl:ENSDARG00000030250 AllianceGenome:ZFIN:ZDB-GENE-041114-34
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dennd2d; zgc:103487
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytosol and nucleoplasm. Orthologous to human DENND2D (DENN domain containing 2D). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (835728..856886)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (818830..839988)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DENN/MADD domain containing 2Db

Names: DENN/MADD domain containing 2D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007346.1 → NP_001007347.1 DENN/MADD domain containing 2Db

See identical proteins and their annotated locations for NP_001007347.1

Status: PROVISIONAL

Source sequence(s)

BC085532

UniProtKB/TrEMBL

Q5U3I4

Related

ENSDARP00000027732.8, ENSDART00000003325.9

Conserved Domains (3) summary

smart00801
Location:387 → 451

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:67 → 157

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

pfam02141
Location:164 → 346

DENN; DENN (AEX-3) domain