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    rcor2 REST corepressor 2 [ Danio rerio (zebrafish) ]

    Gene ID: 402934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rcor2provided by ZNC
    Official Full Name
    REST corepressor 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1812
    See related
    Ensembl:ENSDARG00000008278 AllianceGenome:ZFIN:ZDB-GENE-040426-1812
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77264
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in brain; pectoral fin; and ventral mesoderm. Orthologous to human RCOR2 (REST corepressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rcor2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (24979833..24995613, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (24708676..24724516, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene kelch repeat-containing protein Neighboring gene MAP/microtubule affinity-regulating kinase 2b Neighboring gene N-alpha-acetyltransferase 40, NatD catalytic subunit Neighboring gene beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CoRest1 regulates neurogenesis in a stage-dependent manner. Monestime CM, et al. Dev Dyn, 2019 Oct. PMID 31301200, Free PMC Article
    2. Zebrafish rest regulates developmental gene expression but not neurogenesis. Kok FO, et al. Development, 2012 Oct. PMID 22951640, Free PMC Article
    3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77264

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    REST corepressor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205638.1 → NP_991201.1  REST corepressor 2

      See identical proteins and their annotated locations for NP_991201.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065331
      UniProtKB/Swiss-Prot
      Q6P116
      Related
      ENSDARP00000026854.5, ENSDART00000002961.7
      Conserved Domains (4) summary
      smart00717
      Location:332 → 377
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:332 → 375
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:40 → 92
      ELM2; ELM2 domain
      cl21498
      Location:128 → 172
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      24979833..24995613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172265.5 → XP_005172322.1  REST corepressor 2 isoform X2

      See identical proteins and their annotated locations for XP_005172322.1

      UniProtKB/TrEMBL
      A0A8M2BJM6
      Conserved Domains (4) summary
      smart00717
      Location:294 → 339
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:294 → 337
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:2 → 54
      ELM2; ELM2 domain
      cl21498
      Location:90 → 134
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    2. XM_005172263.5 → XP_005172320.1  REST corepressor 2 isoform X1

      See identical proteins and their annotated locations for XP_005172320.1

      UniProtKB/Swiss-Prot
      Q6P116
      Conserved Domains (4) summary
      smart00717
      Location:332 → 377
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:332 → 375
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:40 → 92
      ELM2; ELM2 domain
      cl21498
      Location:128 → 172
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    3. XM_005172264.4 → XP_005172321.1  REST corepressor 2 isoform X2

      See identical proteins and their annotated locations for XP_005172321.1

      UniProtKB/TrEMBL
      A0A8M2BJM6
      Conserved Domains (4) summary
      smart00717
      Location:294 → 339
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:294 → 337
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:2 → 54
      ELM2; ELM2 domain
      cl21498
      Location:90 → 134
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P116.1 GenPept UniProtKB/Swiss-Prot:Q6P116

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