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    nr1d2b nuclear receptor subfamily 1, group D, member 2b [ Danio rerio (zebrafish) ]

    Gene ID: 30271, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nr1d2bprovided by ZNC
    Official Full Name
    nuclear receptor subfamily 1, group D, member 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-244
    See related
    Ensembl:ENSDARG00000009594 AllianceGenome:ZFIN:ZDB-GENE-990415-244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    reverbb; reverbb2; zgc:92019
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; hormone-mediated signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in nervous system; optic vesicle; and pharyngeal arch. Orthologous to human NR1D2 (nuclear receptor subfamily 1 group D member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nr1d2b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (17400276..17407115)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (17941690..17948550)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor interacting Ras-like 1 Neighboring gene ribosomal protein L15 Neighboring gene uncharacterized LOC137488496 Neighboring gene uncharacterized LOC110438144

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptional and physiological responses induced by binary mixtures of drospirenone and progesterone in zebrafish (Danio rerio). Zucchi S, et al. Environ Sci Technol, 2014 Mar 18. PMID 24568092
    2. Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalpha. Kakizawa T, et al. J Mol Endocrinol, 2007 May. PMID 17496157
    3. Euteleost fish genomes are characterized by expansion of gene families. Robinson-Rechavi M, et al. Genome Res, 2001 May. PMID 11337474, Free PMC Article
    4. Cyclin-dependent kinase inhibitor p20 controls circadian cell-cycle timing. Laranjeiro R, et al. Proc Natl Acad Sci U S A, 2013 Apr 23. PMID 23569261, Free PMC Article
    5. High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation. Wang A, et al. Proc Natl Acad Sci U S A, 2023 May 2. PMID 37094155, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor subfamily 1 group D member 2b
    Names
    NR1D2-B
    Rev-Erb beta 2
    rev erb beta 2
    rev-erb-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131065.1 → NP_571140.1  nuclear receptor subfamily 1 group D member 2b

      See identical proteins and their annotated locations for NP_571140.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074065
      UniProtKB/TrEMBL
      B2GQD8, F6P437, Q6GMI3
      Related
      ENSDARP00000112360.1, ENSDART00000127353.2
      Conserved Domains (2) summary
      cd06940
      Location:388 → 576
      NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
      cd07166
      Location:81 → 169
      NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      17400276..17407115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159500.5 → XP_005159557.1  nuclear receptor subfamily 1 group D member 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B6I7
      Conserved Domains (2) summary
      cd06940
      Location:308 → 496
      NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
      cl02596
      Location:27 → 89
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version

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