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    adgrb1a adhesion G protein-coupled receptor B1a [ Danio rerio (zebrafish) ]

    Gene ID: 563527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adgrb1aprovided by ZNC
    Official Full Name
    adhesion G protein-coupled receptor B1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060607-12
    See related
    Ensembl:ENSDARG00000075133 AllianceGenome:ZFIN:ZDB-GENE-060607-12
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bai1a; wu:fq36h12; si:ch211-80e15.1
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and engulfment of apoptotic cell. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; and negative regulation of angiogenesis. Predicted to be located in membrane. Predicted to be active in dendrite; plasma membrane; and postsynaptic density. Is expressed in muscle; nervous system; and testis. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human ADGRB1 (adhesion G protein-coupled receptor B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See adgrb1a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (37470817..37628454)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (37519733..37678422)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene T-SNARE Domain Containing 1 Neighboring gene histone H1-like protein HC2 Neighboring gene nucleolar protein 58-like Neighboring gene uncharacterized LOC137487947 Neighboring gene uncharacterized LOC137487948

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo. Herzog C, et al. Development, 2019 May 10. PMID 31076485, Free PMC Article
    2. Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Geng FS, et al. Development, 2013 Nov. PMID 24067352, Free PMC Article
    3. Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. Harty BL, et al. BMC Genomics, 2015 Feb 8. PMID 25715737, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in engulfment of apoptotic cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor B1; adhesion G protein-coupled receptor B1a
    Names
    brain-specific angiogenesis inhibitor 1a
    zmp:0000000766

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      37470817..37628454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292551.4 → XP_009290826.1  adhesion G protein-coupled receptor B1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8PX08, A0A8M3AJD7
      Related
      ENSDARP00000145571.1, ENSDART00000188431.1
      Conserved Domains (5) summary
      smart00209
      Location:418 → 468
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:886 → 930
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:665 → 860
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02422
      Location:580 → 646
      HRM; Hormone receptor domain
      cl21561
      Location:944 → 1211
      7tm_4; Olfactory receptor

    2. XM_009292553.4 → XP_009290828.1  adhesion G protein-coupled receptor B1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AQX5
      Conserved Domains (5) summary
      smart00209
      Location:418 → 468
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:886 → 930
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:665 → 860
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02422
      Location:580 → 646
      HRM; Hormone receptor domain
      cl21561
      Location:944 → 1211
      7tm_4; Olfactory receptor

    3. XM_009292556.4 → XP_009290831.1  adhesion G protein-coupled receptor B1 isoform X6

      UniProtKB/TrEMBL
      A0A8M3AJE0
      Conserved Domains (5) summary
      smart00209
      Location:418 → 468
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:944 → 1178
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:886 → 930
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:665 → 860
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02422
      Location:580 → 646
      HRM; Hormone receptor domain

    4. XM_009292552.4 → XP_009290827.1  adhesion G protein-coupled receptor B1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ATQ5
      Conserved Domains (5) summary
      smart00209
      Location:413 → 463
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:881 → 925
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:660 → 855
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02422
      Location:575 → 641
      HRM; Hormone receptor domain
      cl21561
      Location:939 → 1206
      7tm_4; Olfactory receptor

    5. XM_009292559.4 → XP_009290834.1  adhesion G protein-coupled receptor B1 isoform X8

      UniProtKB/TrEMBL
      A0A8M3AQX9
      Conserved Domains (5) summary
      smart00209
      Location:362 → 412
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:830 → 874
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:609 → 804
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02422
      Location:524 → 590
      HRM; Hormone receptor domain
      cl21561
      Location:888 → 1155
      7tm_4; Olfactory receptor

    6. XM_009292560.4 → XP_009290835.1  adhesion G protein-coupled receptor B1 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AIF0
      Conserved Domains (5) summary
      smart00209
      Location:357 → 407
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:825 → 869
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:604 → 799
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02422
      Location:519 → 585
      HRM; Hormone receptor domain
      cl21561
      Location:883 → 1150
      7tm_4; Olfactory receptor

    7. XM_021466979.2 → XP_021322654.1  adhesion G protein-coupled receptor B1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PDS9
      Conserved Domains (5) summary
      smart00209
      Location:383 → 433
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:851 → 895
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:629 → 827
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15990
      Location:904 → 1203
      7tmB2_BAI1; brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02422
      Location:545 → 611
      HRM; Hormone receptor domain

    8. XM_021466981.2 → XP_021322656.1  adhesion G protein-coupled receptor B1 isoform X11

      UniProtKB/TrEMBL
      A0A8M9PK78
      Conserved Domains (5) summary
      smart00209
      Location:327 → 377
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:795 → 839
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:573 → 771
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15990
      Location:848 → 1147
      7tmB2_BAI1; brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02422
      Location:489 → 555
      HRM; Hormone receptor domain

    9. XM_021466982.2 → XP_021322657.1  adhesion G protein-coupled receptor B1 isoform X12

      UniProtKB/TrEMBL
      A0A8M9NZT5
      Conserved Domains (5) summary
      smart00209
      Location:322 → 372
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:790 → 834
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:568 → 766
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15990
      Location:843 → 1142
      7tmB2_BAI1; brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02422
      Location:484 → 550
      HRM; Hormone receptor domain

    10. XM_009292554.4 → XP_009290829.1  adhesion G protein-coupled receptor B1 isoform X4

      UniProtKB/TrEMBL
      A0A2R8PVQ8, A0A8M3AIE6
      Related
      ENSDARP00000144964.1, ENSDART00000192837.1
      Conserved Domains (5) summary
      smart00209
      Location:393 → 443
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:861 → 905
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:640 → 835
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02422
      Location:555 → 621
      HRM; Hormone receptor domain
      cl21561
      Location:919 → 1186
      7tm_4; Olfactory receptor

    11. XM_009292555.4 → XP_009290830.1  adhesion G protein-coupled receptor B1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B1X6
      Conserved Domains (5) summary
      smart00209
      Location:388 → 438
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:856 → 900
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:635 → 830
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02422
      Location:550 → 616
      HRM; Hormone receptor domain
      cl21561
      Location:914 → 1181
      7tm_4; Olfactory receptor

    12. XM_009292562.4 → XP_009290837.1  adhesion G protein-coupled receptor B1 isoform X13

      UniProtKB/TrEMBL
      A0A8M3B1X9
      Conserved Domains (5) summary
      smart00209
      Location:388 → 438
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:914 → 1148
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:856 → 900
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:635 → 830
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02422
      Location:550 → 616
      HRM; Hormone receptor domain

    13. XM_021466980.2 → XP_021322655.1  adhesion G protein-coupled receptor B1 isoform X10

      UniProtKB/TrEMBL
      A0A8M9PN78, E7F9S0
      Related
      ENSDARP00000103202.3, ENSDART00000112003.4
      Conserved Domains (5) summary
      smart00209
      Location:337 → 387
      TSP1; Thrombospondin type 1 repeats
      pfam01825
      Location:805 → 849
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:583 → 781
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15990
      Location:858 → 1157
      7tmB2_BAI1; brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02422
      Location:499 → 565
      HRM; Hormone receptor domain
    Nucleotide Protein
    Heading Accession and Version

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