nudt1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nudt1provided by ZNC
Official Full Name: nudix (nucleoside diphosphate linked moiety X)-type motif 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2757
See related: Ensembl:ENSDARG00000030573 AllianceGenome:ZFIN:ZDB-GENE-040426-2757
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mth1; zgc:56560; wu:fb40g09
Summary: Enables nucleoside triphosphate diphosphatase activity and phosphatase activity. Acts upstream of or within purine deoxyribonucleotide metabolic process. Predicted to be located in cytosol; mitochondrial matrix; and nucleus. Predicted to be active in cytoplasm. Orthologous to human NUDT1 (nudix hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (42121166..42125655, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (41979308..41983797, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables dATP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside triphosphate diphosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA protection	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA protection	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine deoxyribonucleotide metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: oxidized purine nucleoside triphosphate hydrolase

Names: 2-hydroxy-dATP diphosphatase; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; methylated purine nucleoside triphosphate hydrolase; nucleoside diphosphate-linked moiety X motif 1; nudix motif 1

NP_998583.1

EC 3.6.1.56

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213418.1 → NP_998583.1 oxidized purine nucleoside triphosphate hydrolase

See identical proteins and their annotated locations for NP_998583.1

Status: PROVISIONAL

Source sequence(s)

BC049486

UniProtKB/Swiss-Prot

Q7ZWC3

Related

ENSDARP00000040752.5, ENSDART00000040753.6

Conserved Domains (1) summary

cd03427
Location:5 → 140

MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...