nhp2 NHP2 ribonucleoprotein homolog (yeast) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nhp2provided by ZNC
Official Full Name: NHP2 ribonucleoprotein homolog (yeast)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-533
See related: Ensembl:ENSDARG00000069422 AllianceGenome:ZFIN:ZDB-GENE-030131-533
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nola2; zgc:73227; wu:fb36b10; wu:fd61a03
Summary: Predicted to enable box H/ACA snoRNA binding activity. Predicted to be involved in rRNA pseudouridine synthesis; snRNA pseudouridine synthesis; and telomere maintenance via telomerase. Predicted to act upstream of or within rRNA processing. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex and telomerase holoenzyme complex. Is expressed in several structures, including digestive system; immature eye; midbrain; retina; and segmental plate. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Orthologous to human NHP2 (NHP2 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (30401780..30408763, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (30365085..30372068, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fc75e12.x1 (e-PCR)
- UniSTS:194452

fc24d06.y1 (e-PCR)
- UniSTS:193195

fb36b10.x1 (e-PCR)
- UniSTS:190462

fb36b10.x1 (e-PCR)
- UniSTS:190463

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables box H/ACA snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA pseudouridine synthesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in snRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomerase	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of box H/ACA snoRNP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of sno(s)RNA-containing ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of telomerase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: H/ACA ribonucleoprotein complex subunit 2-like protein

Names: nucleolar protein family A member 2-like protein; nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs); snoRNP protein NHP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.