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    tln2a talin 2a [ Danio rerio (zebrafish) ]

    Gene ID: 556842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tln2aprovided by ZNC
    Official Full Name
    talin 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-263
    See related
    Ensembl:ENSDARG00000017901 AllianceGenome:ZFIN:ZDB-GENE-040724-263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tln2; tln1l; zgc:63613; zgc:152648; si:busm1-132m23.1
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in actin cytoskeleton organization and cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in cytoskeleton and ruffle. Predicted to be active in cytoplasm; focal adhesion; and plasma membrane. Is expressed in brain; ectoderm; head; paraxial mesoderm; and somite. Orthologous to human TLN2 (talin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tln2a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (29863548..29946045)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (29592397..29674893)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496174 Neighboring gene serine/threonine-protein kinase pim-3-like Neighboring gene serine/threonine-protein kinase pim-2-like Neighboring gene alpha-tropomyosin Neighboring gene F-box protein 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. Wu Q, et al. FASEB J, 2015 Dec. PMID 26310270, Free PMC Article
    2. Focal adhesions are essential to drive zebrafish heart valve morphogenesis. Gunawan F, et al. J Cell Biol, 2019 Mar 4. PMID 30635353, Free PMC Article
    3. Rear traction forces drive adherent tissue migration in vivo. Yamaguchi N, et al. Nat Cell Biol, 2022 Feb. PMID 35165417, Free PMC Article
    4. Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Thomas-Jinu S, et al. Neuron, 2017 Apr 19. PMID 28392072, Free PMC Article
    5. Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Veerkamp J, et al. Dev Cell, 2013 Mar 25. PMID 23499359

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC63613, MGC152648

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    talin-2a
    Names
    talin 2
    talin1, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201193.2 → NP_957487.2  talin-2a

      Status: VALIDATED

      Source sequence(s)
      BX914219, CU856238
      UniProtKB/TrEMBL
      A0A0R4IIA7, A0A8M2BG54, A0A8N7V044
      Related
      ENSDARP00000133467.2, ENSDART00000168600.2
      Conserved Domains (9) summary
      cd12150
      Location:1656 → 1827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90 → 316
      B41; Band 4.1 homologues
      smart00307
      Location:2338 → 2533
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312 → 403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:206 → 316
      FERM_M; FERM central domain
      pfam08913
      Location:1850 → 1974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494 → 655
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 188
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      29863548..29946045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222309.1 → XP_068078410.1  talin-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BG54, A0A8M6Z7P4

    2. XM_017356865.3 → XP_017212354.1  talin-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BG54, A0A8M6Z7P4
      Conserved Domains (9) summary
      cd12150
      Location:1656 → 1827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90 → 316
      B41; Band 4.1 homologues
      smart00307
      Location:2343 → 2538
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312 → 403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:206 → 316
      FERM_M; FERM central domain
      pfam08913
      Location:1850 → 1974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494 → 655
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 188
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM

    3. XM_009303223.4 → XP_009301498.1  talin-2a isoform X1

      See identical proteins and their annotated locations for XP_009301498.1

      UniProtKB/TrEMBL
      A0A8M2BG54, A0A8M6Z7P4
      Conserved Domains (9) summary
      cd12150
      Location:1656 → 1827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90 → 316
      B41; Band 4.1 homologues
      smart00307
      Location:2343 → 2538
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312 → 403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:206 → 316
      FERM_M; FERM central domain
      pfam08913
      Location:1850 → 1974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494 → 655
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 188
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM

    4. XM_009303222.4 → XP_009301497.1  talin-2a isoform X1

      See identical proteins and their annotated locations for XP_009301497.1

      UniProtKB/TrEMBL
      A0A8M2BG54, A0A8M6Z7P4
      Related
      ENSDARP00000113805.2, ENSDART00000136555.4
      Conserved Domains (9) summary
      cd12150
      Location:1656 → 1827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90 → 316
      B41; Band 4.1 homologues
      smart00307
      Location:2343 → 2538
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312 → 403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:206 → 316
      FERM_M; FERM central domain
      pfam08913
      Location:1850 → 1974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494 → 655
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 188
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM

    5. XM_068222310.1 → XP_068078411.1  talin-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BG54, A0A8M6Z7P4

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394695.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      210433..282088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077755.1: Suppressed sequence

      Description
      NM_001077755.1: This RefSeq was temporarily suppressed because the CDS was partial compared to protein homologs.
    Nucleotide Protein Strain
    Heading Accession and Version

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