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    atg3 autophagy related 3 [ Danio rerio (zebrafish) ]

    Gene ID: 336632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atg3provided by ZNC
    Official Full Name
    autophagy related 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8576
    See related
    Ensembl:ENSDARG00000009350 AllianceGenome:ZFIN:ZDB-GENE-030131-8576
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    apg3l; zgc:64156; im:6910145; wu:fb15g12
    Summary
    Predicted to enable Atg12 transferase activity; Atg8-family conjugating enzyme activity; and Atg8-family ligase activity. Predicted to be involved in autophagy of mitochondrion; macroautophagy; and mitochondrial fragmentation involved in apoptotic process. Predicted to act upstream of or within autophagy and protein transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and phagophore assembly site. Is expressed in several structures, including heart; liver; male organism; muscle; and yolk syncytial layer. Orthologous to human ATG3 (autophagy related 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See atg3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (7109962..7123169, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (6952793..6966000, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene Indian hedgehog signaling molecule b Neighboring gene nonhomologous end-joining factor 1 Neighboring gene G protein-coupled receptor 161a Neighboring gene heparan sulfate 6-O-sulfotransferase 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells. Wu Z, et al. Ecotoxicol Environ Saf, 2021 Sep 15. PMID 34175825
    2. Dilated cardiomyopathy-linked heat shock protein family D member 1 mutations cause up-regulation of reactive oxygen species and autophagy through mitochondrial dysfunction. Enomoto H, et al. Cardiovasc Res, 2021 Mar 21. PMID 32520982
    3. Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish. Yatsuka H, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33333712
    4. Identification and spatiotemporal expression of gpr161 genes in zebrafish. Wang M, et al. Gene, 2020 Mar 10. PMID 31884103
    5. A protective role of autophagy in Pb-induced developmental neurotoxicity in zebrafish. Liu J, et al. Chemosphere, 2019 Nov. PMID 31561294

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Atg12 transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables Atg8-family conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Atg8-family conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables Atg8-family ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Atg8-family ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables aminoacyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fragmentation involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like-conjugating enzyme ATG3
    Names
    APG3 autophagy 3-like
    APG3-like
    autophagy-related protein 3
    NP_956316.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200022.1 → NP_956316.1  ubiquitin-like-conjugating enzyme ATG3

      See identical proteins and their annotated locations for NP_956316.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057434
      UniProtKB/Swiss-Prot
      Q6PFS7
      Related
      ENSDARP00000041303.7, ENSDART00000041304.8
      Conserved Domains (3) summary
      pfam03986
      Location:8 → 133
      Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
      pfam03987
      Location:207 → 268
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
      pfam10381
      Location:289 → 312
      Autophagy_C; Autophagocytosis associated protein C-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      7109962..7123169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFS7.1 GenPept UniProtKB/Swiss-Prot:Q6PFS7

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