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    clasp2 cytoplasmic linker associated protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 404604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clasp2provided by ZNC
    Official Full Name
    cytoplasmic linker associated protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2343
    See related
    Ensembl:ENSDARG00000020345 AllianceGenome:ZFIN:ZDB-GENE-040426-2343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77279
    Summary
    Predicted to enable microtubule plus-end binding activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in microtubule; ruffle membrane; and trans-Golgi network. Predicted to be active in basal cortex; kinetochore; and microtubule cytoskeleton. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See clasp2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (42693558..42802301)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (43124121..43232869)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909275 Neighboring gene sushi domain containing 5 Neighboring gene F-box and leucine-rich repeat protein 2 Neighboring gene upstream binding protein 1 Neighboring gene programmed cell death 6 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Analysis of clasp2 Transcription Pattern in Male Germ Cells during Spermatogenesis: A Comparative Study in Zebrafish (Danio rerio) and Guppy (Poecilia reticulata). Ricci S, et al. Animals (Basel), 2023 Nov 22. PMID 38066968, Free PMC Article
    2. Identification of key genes involved in recovery from spinal cord injury in adult zebrafish. Shen WY, et al. Neural Regen Res, 2022 Jun. PMID 34782579, Free PMC Article
    3. CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development. Klaus A, et al. Cell Rep, 2022 Jun 14. PMID 35705037
    4. Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype. Tonelli F, et al. Matrix Biol, 2020 Aug. PMID 32173581
    5. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
      Title: CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77279

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule plus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exit from mitosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule anchoring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule organizing center organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    CLIP-associating protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328259.1 → NP_001315188.1  CLIP-associating protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX324146
      UniProtKB/TrEMBL
      A0A8M1P4L0, A0A8M3AVR1
      Conserved Domains (3) summary
      pfam02985
      Location:169 → 199
      HEAT; HEAT repeat
      pfam12348
      Location:337 → 538
      CLASP_N; CLASP N terminal
      sd00044
      Location:1332 → 1354
      HEAT; HEAT repeat [structural motif]

    2. NM_207072.2 → NP_996955.1  CLIP-associating protein 2 isoform 2

      See identical proteins and their annotated locations for NP_996955.1

      Status: VALIDATED

      Source sequence(s)
      BX324146
      UniProtKB/Swiss-Prot
      Q6NYW6
      UniProtKB/TrEMBL
      A0A8M3ASU6
      Related
      ENSDARP00000113962.1, ENSDART00000144557.3
      Conserved Domains (2) summary
      pfam12348
      Location:105 → 306
      CLASP_N; CLASP N terminal
      sd00044
      Location:1057 → 1079
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      42693558..42802301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352210.3 → XP_017207699.1  CLIP-associating protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AVR1, A0A8M6YUG3

    2. XM_068215061.1 → XP_068071162.1  CLIP-associating protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ASR7

    3. XM_009294394.4 → XP_009292669.1  CLIP-associating protein 2 isoform X13

      UniProtKB/TrEMBL
      A0A8M3AL48, A0A8M3AVS1
      Conserved Domains (3) summary
      pfam02985
      Location:169 → 199
      HEAT; HEAT repeat
      pfam12348
      Location:337 → 538
      CLASP_N; CLASP N terminal
      sd00044
      Location:1312 → 1334
      HEAT; HEAT repeat [structural motif]

    4. XM_068215073.1 → XP_068071174.1  CLIP-associating protein 2 isoform X16

      UniProtKB/TrEMBL
      A0A8M3AL48

    5. XM_068215060.1 → XP_068071161.1  CLIP-associating protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AVR1

    6. XM_068215062.1 → XP_068071163.1  CLIP-associating protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M3ASR7

    7. XM_068215071.1 → XP_068071172.1  CLIP-associating protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A8M3AL48

    8. XM_068215075.1 → XP_068071176.1  CLIP-associating protein 2 isoform X18

      UniProtKB/TrEMBL
      A0A8M3AL48

    9. XM_068215064.1 → XP_068071165.1  CLIP-associating protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8M3B3Q9

    10. XM_068215076.1 → XP_068071177.1  CLIP-associating protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A8M3B3R7

    11. XM_068215079.1 → XP_068071180.1  CLIP-associating protein 2 isoform X23

      UniProtKB/TrEMBL
      A0A8M3B3R7

    12. XM_068215066.1 → XP_068071167.1  CLIP-associating protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8M3AVR6

    13. XM_009294398.4 → XP_009292673.1  CLIP-associating protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A8M3AL54, A0A8M3B3R7
      Conserved Domains (3) summary
      pfam02985
      Location:169 → 199
      HEAT; HEAT repeat
      pfam12348
      Location:337 → 538
      CLASP_N; CLASP N terminal
      sd00044
      Location:1303 → 1325
      HEAT; HEAT repeat [structural motif]

    14. XM_068215081.1 → XP_068071182.1  CLIP-associating protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A8M3B3R7

    15. XM_068215072.1 → XP_068071173.1  CLIP-associating protein 2 isoform X15

      UniProtKB/TrEMBL
      A0A8M3AST0

    16. XM_068215077.1 → XP_068071178.1  CLIP-associating protein 2 isoform X21

      UniProtKB/TrEMBL
      A0A8M9PGC3

    17. XM_068215078.1 → XP_068071179.1  CLIP-associating protein 2 isoform X22

      UniProtKB/TrEMBL
      A0A8M9PRG1

    18. XM_068215085.1 → XP_068071186.1  CLIP-associating protein 2 isoform X30

      UniProtKB/TrEMBL
      A0A8M3AKF9

    19. XM_068215089.1 → XP_068071190.1  CLIP-associating protein 2 isoform X34

      UniProtKB/TrEMBL
      A0A8M9PN82

    20. XM_068215090.1 → XP_068071191.1  CLIP-associating protein 2 isoform X35

      UniProtKB/TrEMBL
      A0A8M3AL59

    21. XM_068215068.1 → XP_068071169.1  CLIP-associating protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8M3AKE9

    22. XM_068215082.1 → XP_068071183.1  CLIP-associating protein 2 isoform X26

      UniProtKB/TrEMBL
      A0A8M3AL48

    23. XM_009294400.4 → XP_009292675.1  CLIP-associating protein 2 isoform X29

      UniProtKB/TrEMBL
      A0A8M3AST4, A0A8M3AVT1
      Conserved Domains (4) summary
      pfam02985
      Location:169 → 199
      HEAT; HEAT repeat
      pfam12348
      Location:337 → 538
      CLASP_N; CLASP N terminal
      pfam17069
      Location:640 → 894
      RSRP; Arginine/Serine-Rich protein 1
      sd00044
      Location:1276 → 1298
      HEAT; HEAT repeat [structural motif]

    24. XM_068215088.1 → XP_068071189.1  CLIP-associating protein 2 isoform X33

      UniProtKB/TrEMBL
      A0A8M3B3S4

    25. XM_068215092.1 → XP_068071193.1  CLIP-associating protein 2 isoform X37

      UniProtKB/TrEMBL
      A0A8M6Z2X8

    26. XM_068215065.1 → XP_068071166.1  CLIP-associating protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8M3ASS1

    27. XM_068215067.1 → XP_068071168.1  CLIP-associating protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AL44

    28. XM_068215070.1 → XP_068071171.1  CLIP-associating protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A8M3B3R3

    29. XM_068215080.1 → XP_068071181.1  CLIP-associating protein 2 isoform X24

      UniProtKB/TrEMBL
      A0A8M3B3R3

    30. XM_068215084.1 → XP_068071185.1  CLIP-associating protein 2 isoform X28

      UniProtKB/TrEMBL
      A0A8M3AVS6

    31. XM_068215086.1 → XP_068071187.1  CLIP-associating protein 2 isoform X31

      UniProtKB/TrEMBL
      A0A8M3B3S1

    32. XM_009294405.4 → XP_009292680.1  CLIP-associating protein 2 isoform X38

      UniProtKB/TrEMBL
      A0A8M3ASU0, A0A8M3AVT1
      Related
      ENSDARP00000117340.1, ENSDART00000136873.3
      Conserved Domains (3) summary
      pfam02985
      Location:169 → 199
      HEAT; HEAT repeat
      pfam12348
      Location:337 → 538
      CLASP_N; CLASP N terminal
      sd00044
      Location:1258 → 1280
      HEAT; HEAT repeat [structural motif]

    33. XM_068215093.1 → XP_068071194.1  CLIP-associating protein 2 isoform X39

      UniProtKB/TrEMBL
      A0A8M3B3S4

    34. XM_068215063.1 → XP_068071164.1  CLIP-associating protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AKE5

    35. XM_068215087.1 → XP_068071188.1  CLIP-associating protein 2 isoform X32

      UniProtKB/TrEMBL
      A0A8M2B6H8

    36. XM_068215083.1 → XP_068071184.1  CLIP-associating protein 2 isoform X27

      UniProtKB/TrEMBL
      A0A8M2B6H8

    37. XM_068215100.1 → XP_068071201.1  CLIP-associating protein 2 isoform X46

      UniProtKB/TrEMBL
      A0A8M2B6H8

    38. XM_068215096.1 → XP_068071197.1  CLIP-associating protein 2 isoform X42

      UniProtKB/TrEMBL
      A0A8M6YTV4

    39. XM_068215095.1 → XP_068071196.1  CLIP-associating protein 2 isoform X41

      UniProtKB/TrEMBL
      A0A8M6YTV4

    40. XM_068215069.1 → XP_068071170.1  CLIP-associating protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A8M9PAW3

    41. XM_068215091.1 → XP_068071192.1  CLIP-associating protein 2 isoform X36

      UniProtKB/TrEMBL
      A0A8M3AKG2

    42. XM_068215097.1 → XP_068071198.1  CLIP-associating protein 2 isoform X43

      UniProtKB/TrEMBL
      A0A8M6YTV4

    43. XM_068215074.1 → XP_068071175.1  CLIP-associating protein 2 isoform X17

      UniProtKB/TrEMBL
      A0A8M3AKF4

    44. XM_068215094.1 → XP_068071195.1  CLIP-associating protein 2 isoform X40

      UniProtKB/TrEMBL
      A0A8M3B3S4

    45. XM_068215098.1 → XP_068071199.1  CLIP-associating protein 2 isoform X44

      UniProtKB/TrEMBL
      A0A8M6YTV4

    46. XM_068215099.1 → XP_068071200.1  CLIP-associating protein 2 isoform X45

      UniProtKB/TrEMBL
      A0A8M6YTV4

    47. XM_068215101.1 → XP_068071202.1  CLIP-associating protein 2 isoform X48

      UniProtKB/TrEMBL
      A0A8M3AKG9

    48. XM_068215102.1 → XP_068071203.1  CLIP-associating protein 2 isoform X49

      UniProtKB/TrEMBL
      A0A8M3AKG9
      Related
      ENSDARP00000116634.1, ENSDART00000139109.3

    49. XM_009294413.4 → XP_009292688.1  CLIP-associating protein 2 isoform X47

      UniProtKB/TrEMBL
      A0A8M3AL68, A0A8M3B3S6
      Conserved Domains (2) summary
      pfam12348
      Location:109 → 310
      CLASP_N; CLASP N terminal
      sd00044
      Location:1030 → 1052
      HEAT; HEAT repeat [structural motif]

    50. XM_068215103.1 → XP_068071204.1  CLIP-associating protein 2 isoform X50

      UniProtKB/TrEMBL
      A0A8M3B3S6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NYW6.1 GenPept UniProtKB/Swiss-Prot:Q6NYW6

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