U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    msrb1a methionine sulfoxide reductase B1a [ Danio rerio (zebrafish) ]

    Gene ID: 352916, updated on 9-Dec-2024

    Summary

    Official Symbol
    msrb1aprovided by ZNC
    Official Full Name
    methionine sulfoxide reductase B1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030411-3
    See related
    Ensembl:ENSDARG00000025436 AllianceGenome:ZFIN:ZDB-GENE-030411-3
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    MsrB; SePR; selx; cb687; sepx1; SelX-A; sepx1a; MsrB1-A; wu:fa03e09
    Summary
    The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A paralog of this gene (msrb1b) exists on chromosome 12. [provided by RefSeq, Oct 2016]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See msrb1a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (18798431..18805297, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (18649165..18655540, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene hydroxyacylglutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene transportin 2a Neighboring gene small nucleolar RNA SNORD41 Neighboring gene transmembrane protein 104

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-methionine-(R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide-methionine (R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide-methionine (R)-S-oxide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    methionine-R-sulfoxide reductase B1-A
    Names
    methionine-R-sulfoxide reductase B1
    msrB1
    selenoprotein X, 1
    selenoprotein X, 1a
    selenoprotein X-A
    NP_840073.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178288.5NP_840073.2  methionine-R-sulfoxide reductase B1-A

      See identical proteins and their annotated locations for NP_840073.2

      Status: REVIEWED

      Source sequence(s)
      AL772362, EH525837, EH536771, EH572189
      UniProtKB/Swiss-Prot
      Q6NWX6, Q802G6
      Related
      ENSDARP00000122736.1, ENSDART00000131758.3
      Conserved Domains (1) summary
      cl15841
      Location:6110
      SelR; SelR domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      18798431..18805297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)