ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppwd1provided by ZNC
Official Full Name: peptidylprolyl isomerase domain and WD repeat containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-070615-16
See related: Ensembl:ENSDARG00000063161 AllianceGenome:ZFIN:ZDB-GENE-070615-16
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:165355
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within RNA splicing; mRNA processing; and protein peptidyl-prolyl isomerization. Predicted to be part of spliceosomal complex. Orthologous to human PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (11767789..11788565)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (11809553..11830327)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidylprolyl isomerase domain and WD repeat-containing protein 1

NP_001092228.1

EC 5.2.1.8

XP_021334763.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098758.1 → NP_001092228.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1

See identical proteins and their annotated locations for NP_001092228.1

Status: PROVISIONAL

Source sequence(s)

BC142740

UniProtKB/TrEMBL

A5PL48

Related

ENSDARP00000086480.5, ENSDART00000092047.6

Conserved Domains (4) summary

COG2319
Location:64 → 287

WD40; WD40 repeat [General function prediction only]

cd01927
Location:471 → 619

cyclophilin_WD40; cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. ...

sd00039
Location:69 → 107

7WD40; WD40 repeat [structural motif]

cl02567
Location:64 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

11767789..11788565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479088.2 → XP_021334763.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M9Q5R6

Conserved Domains (3) summary

sd00039
Location:69 → 107

7WD40; WD40 repeat [structural motif]

cl00197
Location:471 → 575

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

cl25539
Location:64 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...