txnl4b thioredoxin-like 4B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: txnl4bprovided by ZNC
Official Full Name: thioredoxin-like 4Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051030-63
See related: Ensembl:ENSDARG00000058962 AllianceGenome:ZFIN:ZDB-GENE-051030-63
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:123253; CH73-41E3.4
Summary: Predicted to act upstream of or within mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of U4/U6 x U5 tri-snRNP complex; U5 snRNP; and spliceosomal complex. Orthologous to human TXNL4B (thioredoxin like 4B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (513986..522272)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (518807..522897)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U4/U6 x U5 tri-snRNP complex	IEA Inferred from Electronic Annotation more info
part_of U5 snRNP	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: thioredoxin-like protein 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037123.3 → NP_001032200.1 thioredoxin-like protein 4B

See identical proteins and their annotated locations for NP_001032200.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BQ450264, EH498384, EH591445

UniProtKB/TrEMBL

A0A8M1N7X3, Q3B728

Related

ENSDARP00000076383.3, ENSDART00000081945.4

Conserved Domains (1) summary

cd02986
Location:10 → 123

DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...
NM_001290146.1 → NP_001277075.1 thioredoxin-like protein 4B

See identical proteins and their annotated locations for NP_001277075.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BQ450264, EH437899, EH591445

UniProtKB/TrEMBL

A0A8M1N7X3, Q3B728

Related

ENSDARP00000100887.3, ENSDART00000109083.5

Conserved Domains (1) summary

cd02986
Location:10 → 123

DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

513986..522272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021475835.2 → XP_021331510.1 thioredoxin-like protein 4B isoform X1

UniProtKB/TrEMBL

A0A8M1N7X3, Q3B728

Conserved Domains (1) summary

cd02986
Location:10 → 123

DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...