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    lemd1 LEM domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 436879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lemd1provided by ZNC
    Official Full Name
    LEM domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-350
    See related
    Ensembl:ENSDARG00000040161 AllianceGenome:ZFIN:ZDB-GENE-040718-350
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92287
    Summary
    Predicted to enable DNA binding activity. Predicted to be located in membrane and nuclear envelope. Is expressed in hindbrain; musculature system; myotome; and pectoral fin musculature. Orthologous to human LEMD1 (LEM domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lemd1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (18032569..18057912, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (18106189..18131607, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene peptidase M20 domain containing 1, tandem duplicate 2 Neighboring gene peptidase M20 domain containing 1, tandem duplicate 1 Neighboring gene microRNA 135c-2 Neighboring gene major facilitator superfamily domain containing 4Ab

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LEM domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002606.1 → NP_001002606.1  LEM domain-containing protein 1

      See identical proteins and their annotated locations for NP_001002606.1

      Status: PREDICTED

      Source sequence(s)
      BC075986
      UniProtKB/TrEMBL
      A0A8M1N0S8, A0A8M6YV85, Q6DHI6
      Related
      ENSDARP00000058741.5, ENSDART00000058742.6
      Conserved Domains (2) summary
      cd12940
      Location:75 → 116
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      18032569..18057912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353543.3 → XP_017209032.1  LEM domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B8V4, A0A8M6YXP2
      Related
      ENSDARP00000142311.1, ENSDART00000173068.2

    2. XM_068216729.1 → XP_068072830.1  LEM domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B8V4, A0A8M9PKP3

    3. XM_021469781.2 → XP_021325456.1  LEM domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PT08, A0A8M9PWF4
      Conserved Domains (2) summary
      cd12940
      Location:75 → 116
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:3 → 49
      Thymopoietin; Thymopoietin protein

    4. XM_009296725.4 → XP_009295000.1  LEM domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AV65, A0A8M9PWF4
      Conserved Domains (2) summary
      cd12940
      Location:75 → 116
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    5. XM_005162055.5 → XP_005162112.1  LEM domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B903, A0A8M6YVU6
      Conserved Domains (2) summary
      cd12940
      Location:75 → 116
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein
    Nucleotide Protein
    Heading Accession and Version

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